连续肾脏替代治疗在重症患者急性肾衰竭时的临床疗效

The Clinical Effect of Continuous Renal Replacement Therapy on Acute Renal Failure

目的:观察连续肾脏替代治疗在重症患者急性肾衰竭时的临床疗效。方法:选择2012年1月-2014年6月在本院进行ARF治疗的患者共计56例,分为对照组及治疗组各28例,治疗组采用连续肾脏替代治疗方案,对照组采用间歇肾脏替代治疗方案,4周后观察两组患者观察患者治疗前后BUN、Scr、的实验室指标变化,以及患者并发症发生情况、患者的存活率。结果:4周后,治疗组与对照组BUN、Scr均较治疗前明显下降,且治疗组下降更明显,比较差异具有统计学意义(P<0.05)。治疗组共计发生5例并发症,发生率为17.86%,对照组15例,发生率为53.57%,治疗组并发症发生率明显低于对照组,比较差异有统计学意义(P<0.05)。治疗组死亡4例,病死率为14.29%,对照组死亡12例,病死率为42.86%,治疗组的病死率明显低于对照组,比较差异具有统计学意义(P<0.05)。结论:连续肾脏替代治疗在重症患者急性肾衰竭时的疗效可靠,值得临床推广。

Objective： To observe the clinical effect of continuous renal replacement therapy on treating acute renal failure of severe patients. Method： 56 patients achieved ARF treatment in our hospital from January 2012 to June 2014 were selected, they were divided into control group and treatment group, 28 cases in each group, the treatment group was treated with continuous renal replacement scheme, and the control group used intermittent renal replacement therapy program, to observe BUN, Set, changes of laboratory index, survival rate and occurrence of complications before treatment and after 4 weeks of treatment of the two groups. Result： After 4 weeks , BUN, Scr of the two groups significantly decreased than before treatment, and the treatment group was more obvious than the control group, with statistical significance （ P〈0.05 ） . There were 5 patients occurred complications in the treatment group, the incidence rate was 17.86%, and there were 15 cases in the control group, the incidence was 53.57%. Treatment group＇s incidence was significantly lower than that of the control group, with statistical significance （ P〈0.05 ） . There were 4 cases died in the treatment group, the mortality rate was 14.29%, 12 cases died in the control group, the fatality rate was 42.86%, mortality rates of treatment group was significantly lower than that of the control group, with statistical difference （ P〈0.05 ）. Conclusion： The effect of continuous renal replacement therapy is reliable on treatment of acute renal failure, it is worth the clinical promotion.