1,25（OH）2维生素D3及维生素D受体在慢性肾脏病中的作用

Role of 1,25（ OH）2 vitamin D3 and vitamin D receptor in chronic kidney kiseases

1，25（OH）2维生素D3是维生素D在人体内的活性形式，它通过细胞内特异性维生素D受体发挥着广泛的作用。最近研究表明，1，25（OH）2维生素D3通过与维生素D受体结合，能够保护足细胞，抑制系膜细胞增殖，调节系膜细胞凋亡，延缓肾小管间质纤维化，抑制炎症细胞，减少炎症因子，抑制肾素．血管紧张素系统，对慢性肾脏病起到保护肾功能作用。该文就近年1，25（OH）2维生素D3及维生素D受体在慢性肾脏病中的研究进展作一综述。

1,25 （OH） 2 D vitamin3 is the activated form of vitamin D in human body. Mediated by spe- cific vitamin D receptor,1,25（OH）2 vitamin D3 plays an important role in many physiological and pathological process. In recent years, researches have shown that 1,25 （OH） 2 vitamin D3 can protect podocytes, inhibit the proliferation of mesenteric ceils, regulate the apoptosis of mesenteric cells, anti-inflammation, and have negative effect in rennin-angiotensin system, so as to protect the renal function. This paper reviews the progress of the effect of 1,25（OH）2 vitamin D3 and vitamin D receptor in chronic renal disease.