表观遗传学与哮喘研究进展

Update on the epigenetics and asthma

哮喘是一种气道慢性炎症性疾病，遗传因素及环境因素共同参与其发病。一方面，哮喘与遗传因素密切相关；另一方面，饮食摄入、烟雾暴露、空气污染等外界因素均与其发病相关。新近研究发现，表观遗传学在哮喘发生发展中发挥重要的作用，遗传及环境因素均可影响表观遗传学修饰。因此，该文对哮喘表观遗传学调控及哮喘表观遗传学治疗等方面研究进展加以综述。

Asthma is a chronic airway inflammatory disease, which is caused by both genetic and envi- ronmental factors. For one thing, asthma is associated with genetic factors;for another thing, many exogenous triggering factors, such as diatery intake, smoke exposure and air pollution can impact on the development of asthma. Recently, many studies have showed that epigenetic changes which are influenced by the both factors play an important role in the pathophysiology of asthma. This article reviews the update advances about the epi- genetic regulation and epigenetic therapy in asthma.