Toll样受体在支气管哮喘气道重塑中作用的研究进展

Toll.like receptor and airway remodeling in asthma

支气管哮喘是儿童最常见的慢性呼吸系统疾病之一。气道重塑是哮喘病理变化的重要特征，也是哮喘症状难以控制的重要原因。Toll样受体（Toll—like receptor，TLR）是一种模式识别受体，表达于人呼吸道上皮细胞、平滑肌细胞、黏液腺细胞等多种气道壁结构细胞，在哮喘气道重塑中起重要的调节作用。该文就TLR在支气管哮喘气道重塑中的作用研究进展作一综述。

Bronchial asthma is one of the most common chronic respiratory diseases in children. Airway remodeling that makes asthma difficult to control is an important pathological progress of asthma. Toll-like receptors （TLR） ,a kind of pattern recognition receptors, are expressed in a variety of human airway structure cells, such as airway epithelial cells, smooth muscle cells, mucus gland cells, etc. It is reported that TLRs play important roles in the regulation of airway remodeling in asthma. This article briefly summarizes the role of TLR in airway remodeling of asthma.