促肝细胞生长素联合更昔洛韦治疗婴儿巨细胞病毒肝炎的疗效观察

Curative effects of hepatocyte growth factor in treatment of infant hepatitis syndrome caused by cytomegalovirus with ganciclovir

目的探讨促肝细胞生长素（hepatocyte growth factor，HGF）在更昔洛韦治疗婴儿巨细胞病毒肝炎中的疗效。方法选取2010年9月至2014年9月我院儿科收治的68例（cytomegalovirus，CMV）感染所致婴儿肝炎综合征（infant hepatitis syndrome，IHS）的患儿，分为HGF治疗组32例和常规治疗组36例，所有患儿均给予更昔洛韦抗病毒和常规保肝利胆治疗，HGF治疗组给予HGF辅加治疗，常规治疗组不予HGF治疗。1个月疗程后比较患儿肝功能指标、黄疸消退时间、治疗有效率和不良反应发生率。结果治疗后HGF治疗组患者的肝功能指标较常规治疗组显著改善，黄疸消退时间较早，总体有效率高于常规治疗组（P〈0．05）；两组间不良反应发生率差异无统计学意义（P〉0．05）。结论更昔洛韦联合HGF可显著改善治疗的婴儿期CMV肝炎患儿的肝功能指标，加快临床症状改善，可协同降低CMV-DNA拷贝数，且不良反应少。

Objective To compare the curative effect of hepatocyte growth factor（HGF） in treatment of infant hepatitis syndrome （IHS） caused by cytomegalovirus with ganciclovir. Methods Sixty-eight cases with infant hepatitis syndrome caused by cytomegalovirus from neonatology department of our hospital from September 2010 to September 2014 were randomly divided into two groups, the observation group （32 cases）took HGF and ganciclovir therapy and the control group （36 cases）only received ganciclovir treatment. Both groups were given conventional guard liver therapy. After one month of treatment, liver function, cytomegalovirus DNA content,extinction time of jaundice, treatment efficiency and the adverse reaction rate were evaluated for two groups. Results Liver function of children in observation group improved significantly after treatment compared with the control group, CMV-DNA quantitatively lower than the control group, the extinction time of jaundice was earlier than the latter, and the overall treatment efficiency was higher in observation group （P 〈 0. 05 ） ; The adverse reaction has no significant difference between two groups （P 〉 0. 05）. Conclusion HGF combined with ganciclovir treatment can significantly improve liver function in patients of IHS caused by cytomegalovirus infection,and can collaboratively reduce viral load. Symptoms subside quickly with fewer adverse reactions, which is worthy of clinical promotion.