解读系统生物学:还原论与整体论的综合

Reading of Systems Biology:Integration of Reductionism and Holism

系统生物学的最终目的是解析生命的复杂性。它是21世纪初科学革命的产物,出现于代谢通路理论、生物控制论和各种"组学"的多学科交叉点上,是非线性的"学科整合"的结果。从科学哲学观点看,单纯的还原论与整体论各有局限性,而还原论与整体论的融合则构成系统生物学的哲学基础。"硅细胞"模型表明,计算机模拟和数值实验是系统生物学的有力的方法论工具,提供了揭开生命复杂性之谜的钥匙。生命的涌现性质,是按线性叠加方式是不可计算、不可预测的,却是按非线性叠加方式却是有条件地可计算、可预测的。系统生物学的出现,有力地确证了"系统科学=生物学理论背后的元理论"的观点。

Systems biology is aimed at illustrating the intricate complex life. This discipline is a nonlinear integration derived from cross-disciplinary interviewing of theory of metabolic pathway, biocyberneticsand kinds of omics. This isthe resultof the scientific revolution in the early 21s＇ century. From a philosophical point of view, both reductionismand holism havetheir limitations in analyzingthe complexity of life by themselves, while the integration of the two.While, reconciliation could laya foundation forsystems biology. Silica-cells models tell us that computer simulation and numerical experiments are powerful methodological tools for revealing thepuzzle ofthe complexity of life. While the emergent property is incalculable and unpredictable in terms oflinear superposition, it is calculable and predictable under certain conditions in terms ofnonlinear superposition. Systems biology confirms the proposal that system science be the recta-theory of biology.