新疆维吾尔族系统性红斑狼疮与HLA—DQA1等位基因相关性研究

Association of HLA-DQA1 alleles with systemic lupus erythematosus in populations of Uygur nationality in Xinjiang Uygur Autonomous Region

目的探讨新疆维吾尔族系统性红斑狼疮（SLE）与HLA—DQA1的相关性。方法用聚合酶链反应-序列特异性引物技术．对56例SLE维吾尔族患者和54例维吾尔族健康对照者的HLA—DQA1基因进行研究。结果SLE组DQA1＊0302频率显著高于对照组（F=10．032，P=0．004），而SLE组DQA1＊0101频率显著低于对照组（r=5．676，P=0．017）。结论HLA—DQA1＊0302可能是新疆维吾尔族SLE的易感基因，HIA—DQA1＊0101可能是新疆维吾尔族SLE的保护基因：

Objective To assess the association between HLA-DQA1 alleles and systemic lupus erythematosus （SLE） in populations of Uygur nationality in Xinjiang Uygur Autonomous Region. Methods Polymerase chain reactionsequence-specific primers （PCR-SSP） were used to analyze the HLA-DQA 1 gene in 56 patients with SLE and 54 unrelated healthy controls of Uygur nationality in Xinjiang Uygur Autonomous Region. Results Compared with the healthy controls, the SLE patients showed significantly increased frequency of HLA-DQA1＊0302 （χ^3 = 10.032, P = 0.004）, but decreased frequency ofHLA-DQA1＊0101 （χ^2 = 5.676, P= 0.017）. Conclusion HLA-DQA1＊0302 may be a susceptibility gene, while HLA-DQA1＊0101 may be a protective factor for SLE in populations of Uygur nationality in Xinjiang Uygur Autonomous Region.