摘要
国产、进口庆大霉素荧光偏振免疫试剂测定97份庆大霉素临床血清标本,研究8例气管切开病人庆大霉素气管给药的临床药代动力学。实验结果表明,二种试剂测定比较结果有良好相关性C国产=0.055+0.96C进口(R=0.99)同一病人标本采用二种试剂测定计算出的主要药代动力学参数无显著性差异(p>0.05)。二种试剂批间差相近。
Two gentamicin FPIA reagents were compared by determ-ining 97 clinical samples and doing pharmacokinetics in eight tracheotomypatients after gentamicin trachea administration. There was a significant cor-relationship between the two reagents (p<0.01). No significant differencecould be found between pharmacokinetic paremeters determined by the tworeagents (p>0.05). Inter CV of the two reagents in one month is similar(p>0.05).
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1991年第4期225-227,共3页
The Chinese Journal of Clinical Pharmacology
关键词
庆大霉素
荧光偏振免疫
测定
gentamicin
therapeutic drug monitoring
FPIA