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环己基(三甲基硅基亚甲基)锡二芳香酸酯的合成、结构和抗癌活性 被引量：1

Synthesis,Structure and Antitumour Activity of Cyclohexyl(( trimethylsilyl) methyl) stannanediyl Bisarylcarboxylates
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摘要 采用环己基(三甲基硅基亚甲基)二氯化锡和芳香酸(物质的量比1∶2)在三乙胺存在下,合成了8种新的混合二烃基锡化合物环己基(三甲基硅基亚甲基)锡二芳香酸酯。通过IR、1H NMR、13C NMR和元素分析等技术手段对它们的结构进行了表征;部分化合物的生物活性测定初步结果表明,它们对肺腺癌细胞(A549)有较好的体外抗癌活性,抑制率均在75%以上。 Eight cyclohexyl（（trimethylsilyl） methyl）stannanediyl bisarylcarboxylates were synthesized by the reaction of cyclohexyl （trimethylsilylmethyl）tin dichloride with arylcarboxylic acids. These compounds were characterized by IR, 1H NMR and 13C NMR spectra and elemental analysis. The preliminary bioassay tests of these compounds show good antitumour activities in vitro against tumour cells A549 and the inhibition rates are over 75%.
作者 林森 吴亚弟 邓瑞红 曹迁永
机构地区 南昌大学化学系
出处 《应用化学》 CAS CSCD 北大核心 2015年第10期1114-1119,共6页 Chinese Journal of Applied Chemistry
基金 国家自然科学基金资助项目(21162017)~~
关键词 二烃基锡 合成 结构 抗癌活性 diorganotin synthesis structure antitumour activity
分类号 O627.4 [理学—有机化学]
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参考文献18

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二级参考文献25

共引文献26

同被引文献15

  • 1林森,邓瑞红,卢志强,孙小强,汪信,陆路德.二(三甲硅亚甲基)锡二芳香羧酸酯的合成和结构表征[J].有机化学,2005,25(10):1298-1301. 被引量：14
  • 2Alama A,Tasso B,Novelli F,et al. Organometallic compoundsin oncology:implications of novel organotins as antitumoragents [J]. Drug Discov Today,2009,14:500-508.
  • 3Ferreira I P,De Lima G M,Paniago E B,et al. Design,structural and spectroscopic elucidation,and the in vitrobiological activities of new diorganotin dithiocarbamates[J]. Eur J Med Chem,2012,58:493-503.
  • 4Gielen M,Biesemans M,Willem R. Organotin compounds:from kinetics to stereochemistry and antitumour activities[J]. Appl Organomet Chem,2005,19:440-450.
  • 5Basu Baul T S,Masharing C,Basu S,et al. Synthesis,characterization,cytotoxic activity and crystal structures of trianddi-organotin(IV) complexes constructed from the β-{[(E)-1-(2-hydroxyaryl) alkylidene] amino} propionateand β-{[(2Z)-(3-hydroxy-1-methyl-2-butenylidene)] amino}propionate skeletons [J]. J. Organomet Chem,2006,691:952-965.
  • 6Nath M,Pokharia S,Song X,et al. New organotin(IV)derivativesof dipeptides as models for metal-protein interactions:in vitro anti-tumour activity [J]. Appl OrganometChem,2003,17(10):823-823.
  • 7Tabassum S,Yadav S,Arjmand F. Exploration of glycosylated-organotin(IV) complexes as anticancer drug candidates[J]. Inorg Chim Acta,2014,423:38-45.
  • 8Nath M,Saini P K. Chemistry and applications of organotin(IV)complexes of Schiff bases[J]. Dalton Trans,2011,40:7 077-7 121.
  • 9Batra N,Malhotra N,Assija S. Organotin(IV) complexeswith ONS donor Schiff base ligand:Synthesis,characterizationand antimicrobial evaluation[J]. J Chem Pharm Res,2014,6(9):194-200.
  • 10Hadjikakou S K,Hadjiliadis N. Antiproliferative and antitumoractivity of organotin compounds[J]. Coord ChemRev,2009,253:235-249.

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应用化学
2015年 第10期

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