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三环已基锡L-扁桃酸酯配合物的合成、结构及性质 被引量:2

Synthesis,Structure and Properties of Tricyclohexyltin L-Mandeliate
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摘要 三环己基氢氧化锡与L-扁桃酸(物质的量比1∶1)在苯和乙醇混合溶剂中反应合成了三环己基锡L-扁桃酸酯。经X射线衍射方法测定了其晶体结构,配合物属斜方晶系,空间群为P212121,晶体学参数a=0.80825(4)nm,b=1.77151(8)nm,c=1.8385(2)nm,α=β=γ=90°,V=2.6324(2)nm3,Z=4,Dc=1.310 g/nm3,μ(Mo Kα)=9.92 cm-1,F(000)=1080,R1=0.0472,wR2=0.1341。中心锡原子与环己基碳原子和氧原子构成畸型四面体。对其结构进行量子化学从头计算,探讨了配合物的稳定性、分子轨道能量以及一些前沿分子轨道的组成特征。研究了配合物的热稳定性、电化学性能、圆二色谱和体外抗癌活性。 Tricyclohexyhin L-mandeliate was synthesized by the reaction of tricyclohexyhin hydroxide with L-mandelic acid. Its structure has been determined by X-ray single crystal diffraction. The crystal is orthorhombic with space group P212121 , a = 0. 80825 (4) nm, b = 1.77151 (8) nm, c = 1. 8385 (2) nm, α =β =γ =90°, V=2. 6324(2) nm3, Z =4, Dc = 1. 310 g/nm3, μ(MoKa) =9.92 cm-1, F(000) = 1080, R1 = 0.0472, wR2 = 0. 1341. The tin atom has a distorted tetrahedral geometry. The stability of tricyclohexyhin L-mandeliate, its orbital energies and composition characteristics of some frontier molecular orbitals have been investigated by quantum chemistry calculation by means of G03W package and taking Lanl2dz basis set. Further more, thermal stability, electrochemical property, CD spectrum and anticancer activity of tricyclohexyhin L-mandeliate were also tested.
出处 《应用化学》 CAS CSCD 北大核心 2015年第10期1120-1126,共7页 Chinese Journal of Applied Chemistry
基金 湖南省高校创新平台开放基金项目(15K107) 湖南省自然科学基金项目(11JJ3021) 湖南省重点学科基金 湖南省高校科技创新团队支持计划 湖南省高校重点实验室开放基金资助~~
关键词 三环己基锡L-扁桃酸酯 合成 结构 抗癌活性 tricyclohexyhin L-mandeliate synthesis structure antitumor activity
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  • 1Chandrasekhar V, Thirumoorthi R, Metre R K, et al. Steric Control in the Reactions of 3-Pyrazolecarboxylic Acid with Diorganotin Dichlorides [ J ]. J Organomet Chem,2011,696 :600-606.
  • 2Effendy, Marchetti F, Marinelli A,et al. Binuclear Diorganotin (IV) Complexes with Bis (O, O'-4-acyl-5-pyrazolonato)bis (bidentate) Ligands [ J ]. Inorg Chem Acta,2011,366 : 388-393.
  • 3Sedaghat T,Aminian M,Bruno G,et al. Binuclear Organotin(IV) Complexes with Adipic Dihydrazones:Synthesis, Spectral Characterization, Crystal Structures and Antibacterial Activity[J]. J Organomet Chem,2013,737:26-31.
  • 4张晓燕,杨光,张俊,曾广同,唐良富.有机锡2-[(1,2,4-三唑-1-基)甲基硫代]苯甲酸酯的合成与生物活性[J].高等学校化学学报,2010,31(6):1162-1166. 被引量:12
  • 5Hong M ,Yin H D,Zhang X Y,et al. Di- and Tri-organotin( IV ) Complexes with 2-Hydroxy-l-naphthaldehyde 5-Chloro-2- hydroxybenzoylhydrazone :Synthesis, Characterization and in Vitro Antitumor Activities [ J ]. J Organomet Chem ,2013 , 724 : 23-31.
  • 6Gielen M, Davies A G, Pannell K,et al. Tin Chemistry : Fundamentals, Frontiers, and Applications [ M ]. Weinheim : John Wiley & Sons Inc,2008:413-417.
  • 7张志坚,邝代治,张复兴,庾江喜,蒋伍玖.三(2-甲基-2-苯基)丙基锡(Ⅳ)三氯乙酸酯的合成、结构和生物活性[J].应用化学,2014,31(9):1058-1062. 被引量:6
  • 8Carraher J C E,Roner M R. Organotin Polymers as Anticancer and Antiviral Agents[ J]. J Organomet Chem,2014,751: 67 -82.
  • 9Sun M L, Ruan B F, Tian Y P,et al. Synthesis, Crystal Structures, Electro Chemical Studies and Anti-tumor Activities of Three Polynuclear Organotin ( 1V ) C arboxylates Containing Ferrocenyl Moiety [ J ]. J Organomet Chem, 2011,696 : 3180- 3185.
  • 10Ruan B F,Tian Y P,Wu J Y,et al. Synthesis, Characterization and in Vitro Antitumor Activity of Three Organotin( IV ) Complexes with Carbazole Ligand[ J]. Inorg Chem Acta,2011,365( 1 ) :302-308.

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