非高密度脂蛋白胆固醇与心脑血管疾病关系研究进展

Research Progress on Non-High-Density Lipoprotein Cholesteral and Cardiovascular and Cerebrovascular Diseases

非高密度脂蛋白胆固醇(non-high-density lipoprotein cholesterol,non-HDL-C)反映致动脉粥样硬化胆固醇的总量,美国国家胆固醇教育计划中的成人治疗专家方案第3号报告中首次提出这一概念,并且将其作为降脂治疗的第二目标。目前已广泛证实non-HDL-C在冠状动脉粥样硬化性心脏病发病率及死亡率方面的预测价值较高,甚至可能优于传统血脂指标。但non-HDL-C与脑血管病相关的研究有限且结果存在争议,本文就non-HDL-C与心脑血管病相关的研究现状做一综述。

Non-high-density lipoprotein cholesterol （non-HDL-C） relfects the total amount of atherogenic cholesterol. The concept of non-HDL-C was ifrst proposed on the National Cholesteral Education Program Adult Treatment Panel III and was assigned to be the second target for lipid-lowering therapy. More and more recent studies at home and abroad have shown that the non-HDL-C could be a more accurate predictor of morbidity and morality of coronary atherosclerotic heart disease than traditional markers such as low density lipoprotein cholesterol. Currently, there are less and scattered research on the association between non-HDL-C and cerebrovascular diseases. This review aims to summarize and analyze the research progress of non-HDL-C.