利湿祛瘀法治疗Ⅲ型前列腺炎疗效及对相关免疫学因素的影响

Influence of Eliminating Dampness and Resolving Blood Stasis Method on Related Immunological Factors and PSA of Ⅲ Prostatitis

目的:分析利湿祛瘀法治疗Ⅲ型前列腺炎疗效及对相关免疫学因素的影响。方法:选取2013年12月—2014年12月收治的Ⅲ型前列腺炎患者150例,按照随机数字表法分为研究组和对照组,每组75例,研究组给予利湿祛瘀法治疗,对照组给予抗生素治疗,两组均治疗2个月,测定两组治疗前后的相关免疫学指标和总前列腺特异抗原(TPSA)、游离前列腺特异抗原(FPSA),应用慢性前列腺炎症状评分(NIH-CPSI)表评定临床症状评分和整体评分。结果:治疗后两组NIH-CPSI临床症状评分和整体评分显著优于治疗前,与治疗前比较差异具有统计学意义(P<0.05),且研究组优于对照组,两组比较差异具有统计学意义(P<0.05);治疗后两组TPSA和FPSA/TPSA均优于治疗前,与治疗前比较差异具有统计学意义(P<0.05),且研究组优于对照组,两组比较差异具有统计学意义(P<0.05);治疗前、治疗后两组CD4+、CD8+比较均无统计学意义(P>0.05),治疗后研究组CD4+/CD8+明显高于对照组(P<0.05)。结论:利湿祛瘀法治疗Ⅲ型前列腺炎能显著改善NIH-CPSI评分,降低TPSA,且对免疫功能具有稳定作用。

Objective： To study the influence of eliminating dampness and resolving blood stasis method on related immunologieal factors and prostate -specific antigen （PSA） of Ⅲ prostatitis. Methods ：150 cases with Ⅲ prostatitis were selected from our hospital during December 2013 to December 2014. They were divided into the study group and the control group according to a random number table ,75 cases in each group. The study group were given eliminating dampness and resolving blood stasis method and the control group were given antibiotic. Both groups were treated for 2 months,relevant immunological parameters and total prostate -specific antigen （TPSA） and free prostate specific antigen （FPSA） before and after treatment of two groups were detected. The clinical symptom scores and overall scores were assessed in chronic prostatitis symptom score （NIH -CPSI）. Resuhs：NIH -CPSI clinical symptom scores and overall scores after treatment of two groups were significantly better than that before treatment and the difference was statistically significant（P 〈 0.05 ）. And the study group was better than the control group and the difference was statistically significant （P 〈 0.05 ）. TPSA and FPSA/TPSA after treatment of two groups were significantly better than that before treatment and the difference was statistically significant（ P 〈0.05） and the study group was better than the control group and the difference was statistically significant（P 〈 0.05 ）. CD4 ^＋ and CD8^ ＋ of two groups had no statistical significance after treatment （ P 〉 0.05 ）. Conclusion：The eliminating dampness and resolving blood stasis method in treatment of Ⅲ prostatitis can significantly improve the NIH -CPSI score and reduce TPSA and has a stabilizing effect on the immune function.