具有除草活性的AHAS抑制剂小分子的研究进展

Progress of the research on the herbicidal activity of AHAS inhibitors

乙酰羟酸合成酶(AHAS)抑制剂是上世纪80年代开发兴起的一种新型除草剂,具有广谱、高效、低毒等特点,现已被广泛应用于田间的杂草防治.近年来,基于乙酰羟酸合成酶为靶标的抑制剂被大量开发.现将从抑制剂分子结构与生物活性方面概述磺酰脲类、三唑并嘧啶类、嘧啶水杨酸类以及三唑啉酮类等AHAS抑制剂的发展过程与研究进展.

Acetohydroxyacid synthase（AHAS）inhibitors, which were developed in the 1980s, have been widely used as new herbicide for preventing and eliminating weeds in the fields. Since the past few years, abundant AHAS inhibitors have been developed. This paper provided a overview of the structure and bioactiyity of AHAS inhibitors including sulfonylureas, triazolopyrimidines, pyrimidylsalicylate and triazolinones derivatives,which are classed according to the different types of pharmacophores.