女性糖尿病患者鼾症、睡眠时长与心血管疾病标志物的相关性研究

Correlation between snoring,sleeping duration and cardiovascular disease markers in female diabetic patients

目的研究女性2型糖尿病患者鼾症以及睡眠时长与心血管疾病标志物的相关性。方法女性2型糖尿病伴鼾症患者121例,对其一般情况、睡眠时长以及鼾症频率进行问卷调查,根据不同打鼾频率分为偶尔（n=13）、很少（n=79）、经常（n=29）,又根据睡眠时长分为≤5 h（n=15）、6∽7 h（n=56）、8 h（n=29）、≥9 h（n=21）,分析其与心血管疾病标志物的相关性。结果不同打鼾频率患者HDL-c、TG、CRP、sTNFαRⅡ水平差异有统计学意义,打鼾频率高的患者血清TC、CRP、sTNFαRⅡ较高,HDL-C较低（P〈0.05）,而TC、LDL-C水平差异无统计学意义（P〉0.05）。不同睡眠时长患者CRP水平差异有统计学意义（P〈0.01）,睡眠时间长者CRP水平增高（P〈0.01）,其他指标差异无统计学意义（P〉0.05）。结论鼾症频率和睡眠时间与血脂水平以及炎性标志物相关联,为解释鼾症与心血管疾病、代谢疾病发病的相关性提供了理论基础。

Objective To investigate women with type 2 diabetes and snore , and the correlation between sleep length and markers of cardiovascular disease .Methods One hundred and twenty one female cases with type 2 diabetes mellitus and snoring were enrolled , questionnaire survey of the general situation , sleep duration and snoring frequency were investigated , depending on the frequency of snoring , they were divided into occasionally （ n =13 ） , rarely （ n =79 ） , often （ n =29 ） , and according to sleep length, they were divided into ≤5 h （ n =15）, 6--7 h （ n =56）, 8 h （ n =29）, ≥9 h（ n =21）.Analyzed the correlation with cardiovascular disease associated markers .Results There were differences of HDL-C, TG,CRP and sTNFαRII levels in patients with different snoring frequency , high frequency of snoring patients ’ serum TG, CRP and sTNFαRII were increased and HDL-C were decreased （ P 〈0.05）, and TC, LDL-C levels did not show statistical significance（ P 〉0.05）.Different sleep length patients with different CRP level （ P 〈0.01）, increased sleep time with higher CRP levels （ P 〈0.01）, the differences of other indexes did not show statistical significance （ P 〉0.05）.Conclu-sion Snoring frequency and duration of sleep , blood lipid level and inflammatory indicators were correlated , which provides a theoretical basis for explaining the relationship between snoring and cardiovascular disease , metabolic disease .