高剂量方案治疗复治肺结核疗效观察

Effect of high-dose regimen for the retreatment of tuberculosis

目的探讨采用高剂量方案治疗复治菌阳肺结核患者的临床效果,为临床抗结核药物的科学使用提供依据。方法将复治菌阳肺结核患者91例随机分为两组,即高剂量组(4HL2+Lf X+EZ/4HL2E)和常规量组(2HRZES/6HRE)。治疗8个月后对两组患者痰菌阴转率、痰菌培养阳性率、病灶有效吸收率、空洞闭合率等进行比较分析。结果高剂量组患者菌阴转率、痰菌培养阳性率、病灶有效吸收率和空洞闭合率分别为95.6%、4.4%、84.4%、74.4%,明显优于常规量组患者的65.2%、21.7%、50.0%、52.5%,两组比较差异均有统计学意义(P<0.05)。结论使用高剂量方案治疗复治菌阳肺结核,临床效果好,安全性高,是可行的治疗方案。

Objective to investigate the clinical effect of high-dose regimen for the retreatment of tuberculosis, providing clinical evidence for the application of anti-tuberculosis drugs. Methods A total of 91 with pulmonary tuberculosis who underwent retreatment were randomly divided into high-dose group （4HL2 ＋ LfX ＋ EZ/4HL2E ） and regular-dose group （2HRZES/6HRE）. After 8 months of treatment, sputum conversion rate, positive rate of sputum culture, focal absorption rate, and cavity closure rate between the two groups were compared. Results After treatment, the sputum conversion rate （95.6%）, positive rate of sputum culture （4.4%）, focal absorption rate （84.4%）, and cavity closure rate （74.4%） of high-dose group were higher than those of regular-dose group which was 65.2% ,21.7%, 50.0%, and 52.5%, respectively. There was a significant difference between the two groups. Conclusions High-dose regimen has favorable outcomes in relapsing pulmonary tuberculosis, which is a safe and feasible theraputic approach.