期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

中性粒细胞明胶酶相关脂质运载蛋白对腹膜透析相关性腹膜炎疗效监测的意义 被引量：2

Application of neutrophil gelatinase-associated lipocalin for peritoneal dialysis-related peritonitis to supervise curative effect
原文传递
导出
摘要 目的探讨腹膜透析相关性腹膜炎患者中性粒细胞明胶酶相关脂质运载蛋白(NGAL)的表达与变化对疾病监测的意义。方法选择本中心收治的50例腹膜透析引出液细菌培养阳性的腹膜透析相关性腹膜炎患者,所选病例经头孢唑林1.0 g与头孢他啶1.0 g治疗2周后均痊愈。采集所有患者的临床资料、血和腹膜透析引出液标本,检测第1、3、7、14、21天外周血与腹膜透析引出液标本中WBC、NEU%、超敏C反应蛋白(hs-CRP)与IL-1β、TNF-α、NGAL的浓度。结果患者外周血NGAL水平在第1天为(1 725.6±341.2)ng/ml,而3 d后则迅速降至(1 130.4±234.6)pg/ml(P<0.05),2周后回落至(490.3±149.1)pg/ml(P<0.05),与3周后的NGAL水平[(452.7±137.2)pg/ml]之间无统计学差异,提示NGAL比其他指标的变化更为灵敏。结论根据腹膜透析相关性腹膜炎患者的血清NGAL水平可以较快速准确地评估腹膜炎的病情,可作为疗效监测的一个良好生物学指标。 ObjectiveTo evaluate the expression of neutrophil gelatinase-associated lipocalin （NGAL） in patients with peritoneal dialysis-related peritonitis and the clinical significance of monitoring . MethodsFifty cases of peritoneal dialysis-related peritonitis patients with positive culture results of bacteria in dialysis effluent were selected. All of these patients were cured with 1.0 g cefazolin and 1.0 g ceftazidime. The clinical information, peritoneal dialysis effluent and blood specimens were collected to examine the concentration of high-sensitivity C-reactive protein （hs-CRP）, IL-1 beta, TNF-alpha and NGAL at day 1, 3, 7, 14 and 21.Results The NGAL level of serum was （1 725.6±341.2）ng/ml at day 1 and declined to （1 130.4±234.6）pg/ml rapidly after treating for 3 days （P〈0.05）. The NGAL level of serum fell back to （490.3±149.1）pg/ml （P〈0.05） at day 14 and recovered to baseline level [（452.7±137.2） pg/ml] at day 21. The level had no difference between day 14 and day 21. The serum NGAL changed more sensitive than the other markers.ConclusionThe NGAL level of serum in peritoneal dialysis-related peritonitis patients could reflect the severity of peritonitis quickly and accurately. It might be used as a good biological indicator to monitor therapeutic effect.
作者 朱伟平 陈柏荣 林琳 张桦 李中和
机构地区 中山大学附属第五医院肾内科 中山大学附属第五医院心内科
出处 《中华临床医师杂志（电子版）》 CAS 2015年第17期16-19,共4页 Chinese Journal of Clinicians(Electronic Edition)
基金 珠海市科技计划项目(201111140013)
关键词 腹膜透析 腹膜炎 肿瘤坏死因子Α 白细胞介素1 中性粒细胞明胶酶相关脂质运载蛋白 Peritoneal dialysis Peritonitis Tumor necrosis factor-alpha Interleukin-1 Neutrophil gelatinase-associated lipocalin
分类号 R459.5 [医药卫生—治疗学] R572.2 [医药卫生—消化系统]
  • 相关文献

参考文献15

  • 1须静,胡晓波.中性粒细胞明胶酶相关脂质运载蛋白的研究进展[J].检验医学,2012,27(10):871-876. 被引量：27
  • 2Lenng JC, I.am MF, Tang SC, et al. Roles of neutrophil gelafinase-associated fipocalin in continuous ambulatory peritoneal dialysis-related peritomtis[J]. J Clin Immunot, 2009, 29(3): 365-378.
  • 3Martino FK, Filippi I, Giavarina D, et al. Neutrophil gelatinase-associated lipocalin in the early diagnosis of peritonitis: the case of nentrophil gelatinase-associated lipocalin[J]. Contrib Nephrol, 2012, 178: 258-263.
  • 4Martino F, Scalzotto E, Giavarma D, et al. The role of ngal in peritoneal dialysis effluent in early diagnosis of peritonitis: case-control study in peritoneal dialysis patients[J]. Perit Dial Int, 2014:pdi.2013,00300.
  • 5Virzi GM, Clementi A, de Cal M, et al. Genomics and biological activity of neutrophil gelatinase-associated lipocalin in several clinical settings[J]. Blood Purif, 2013, 35(1/3): 139-143.
  • 6Martensson J, BeUomo R. The rise and fall of NGAL in acute kidney injury[J]. Blood Purif, 2014, 37(4): 304-310.
  • 7Nasioudis D, Witkin SS. Neutmphil gelatinase-associated lipocalin and innate immune responses to bacterial infections[J]. Med Microbiol Immunol, 2015, 204(4): 471-479.
  • 8Klausen P, Niemann CU, Cowland JB, et al. On mouse and man: nentrophil gelafinase associated lipocalin is not involved in apoptusis or acute response[J]. Eur J Haematol, 2005, 75(4): 332-340.
  • 9Srinivasan G, Aitken JD, Zhang B, et al. Lipocalin 2 deficiency dysregnlates iron homeostasis and exacerbates endotoxin-induced sepsis[J]. J Immtmol, 2012, 189(4): 1911-1919.
  • 10Lippi G, Caleffi A, Pipitonc S, vt al. Assessment of nvutrophil gelatinase-associated lipocalin and lactate dehydrogenase in peritoneal fluids for the screening of bacterial peritonitis[J]. Clin China Acta, 2013, 418: 59-62.

二级参考文献42

  • 1Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction failure[J]. Intensive Care Med, 1996, 22:707-710.
  • 2Gursel G, Demirtas S.Value of APACHE Ⅱ, SOFA and CPIS scores in predicting prognosis in patients with ventilator-associated pneumonia [J]. Respiration. 2005,30(9) : 1204-1233.
  • 3Siddiqui S, Ahmed S, Martasia R. Apache Ⅱ score as a predictor of length of stay and outcome in our ICUs[J]. J Pak Med Assoc, 2005, 55 (6) : 253-254.
  • 4Gurleyik G, Gurleyik E, Unalmiser S. Abdominal surgical emergency in the elderly[J]. Turk J Gastroenterology, 2002,13 (1):47-52.
  • 5Kriwanek S, Armbruster C, Beckerhinn P, et al. Prognostic factors for survival in colonic perforation[J].Int J Colorect Dis, 1994, 9:155-162.
  • 6Komatsu S, Shimomatsuya T, Nakajima M, et al. Prognostic factors and scoring system for survival in colonic perforation[J]. Hepatogastroenterology. 2005, 52(63) :761-764.
  • 7Kjeldsen L, Johnsen AH, Sengelov H, et al. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase [ J ]. J Bi- d Chem, 1993,268 (14) : 10425-10432.
  • 8Cowland JB, Borregaard N. Molecular characterization and pattern of tissue expression of the gene for neutro- phil gelatinase-associated lipocalin from humans [ J ]. Genomics, 1997,45 ( 1 ) : 17-23.
  • 9Borregaard N, Sehested M, Nielsen BS. et al. Biosyn- thesis of granule proteins in normal human bonemarrow cells. Gelatinase is a marker of terminal neu- trophil differentiation[ J]. Blood, 1995,85 (3) : 812- 817.
  • 10Friedl A, Stoesz SP, Buckley P, et al. Neutrophil gela- tinase-associated lipeoealin in normal and neoplastic human tissues. Cell type-specific pattern of expres- sion[J]. Histochem J,1999,31 (7) :433-441.

共引文献39

同被引文献15

  • 1章凌华,乐革芬.4种危重评分系统在老年急性腹膜炎患者预后评估中应用的比较[J].中华护理杂志,2007,42(11):1004-1006. 被引量：11
  • 2Lenng JC, I.am MF, Tang SC, et al. Roles of neutrophil gelafinase-associated fipocalin in continuous ambulatory peritoneal dialysis-related peritomtis[J]. J Clin Immunot, 2009, 29(3): 365-378.
  • 3Martino FK, Filippi I, Giavarina D, et al. Neutrophil gelatinase-associated lipocalin in the early diagnosis of peritonitis: the case of nentrophil gelatinase-associated lipocalin[J]. Contrib Nephrol, 2012, 178: 258-263.
  • 4Martino F, Scalzotto E, Giavarma D, et al. The role of ngal in peritoneal dialysis effluent in early diagnosis of peritonitis: case-control study in peritoneal dialysis patients[J]. Perit Dial Int, 2014:pdi.2013,00300.
  • 5Virzi GM, Clementi A, de Cal M, et al. Genomics and biological activity of neutrophil gelatinase-associated lipocalin in several clinical settings[J]. Blood Purif, 2013, 35(1/3): 139-143.
  • 6Martensson J, BeUomo R. The rise and fall of NGAL in acute kidney injury[J]. Blood Purif, 2014, 37(4): 304-310.
  • 7Nasioudis D, Witkin SS. Neutmphil gelatinase-associated lipocalin and innate immune responses to bacterial infections[J]. Med Microbiol Immunol, 2015, 204(4): 471-479.
  • 8Klausen P, Niemann CU, Cowland JB, et al. On mouse and man: nentrophil gelafinase associated lipocalin is not involved in apoptusis or acute response[J]. Eur J Haematol, 2005, 75(4): 332-340.
  • 9Srinivasan G, Aitken JD, Zhang B, et al. Lipocalin 2 deficiency dysregnlates iron homeostasis and exacerbates endotoxin-induced sepsis[J]. J Immtmol, 2012, 189(4): 1911-1919.
  • 10Lippi G, Caleffi A, Pipitonc S, vt al. Assessment of nvutrophil gelatinase-associated lipocalin and lactate dehydrogenase in peritoneal fluids for the screening of bacterial peritonitis[J]. Clin China Acta, 2013, 418: 59-62.

引证文献2

二级引证文献15

中华临床医师杂志（电子版）
2015年 第17期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部