摘要
目的：探讨PinX1在结直肠癌中的表达及其临床意义。方法收集83例结直肠癌和癌旁组织蜡块，所有患者均接受5-氟尿嘧啶（5-Fu）及其衍生物为基础的辅助化疗4～6个周期，免疫组化检测PinX1蛋白的表达，并分析其与临床病理特征及预后的关系，率的分析采取卡方检验，生存分析应用Kaplan-Meier法和Cox风险比例模型。结果36例（43.4%）癌组织的PinX1蛋白呈低表达，而在相应癌旁组织中，仅8例（9.6%）呈低表达，差异有统计学意义（P＜0.05）。尽管PinX1表达下调与临床病理参数无关，经生存分析和Cox风险比例回归模型显示，PinX1表达下调是OS及DFS的独立预后指标。结论PinX1表达下调在结直肠癌发生发展中起重要作用，并可能成为5-Fu辅助化疗结直肠癌患者预后判断指标。
ObjectiveTo explore the expression of PinX1 protein in colorectal cancer （CRC） tissues and its clinical significance.Methods A total of 83 paired CRC specimens and their adjacent normal tissues were collected, all of the patients received 4-6 cycles of 5-fluorouracil （5-Fu） based adjuvant chemotherapy. PinX1 protein expression was analyzed by immunohistochemical staining, its correlations with clinicopathological factors and prognosis were further evaluated.Results PinX1 expression was decreased in 36 tumor tissues （43.4%）, while only decreased in 8 adjacent normal tissues （9.6%）, which was statistically significant （P〈0.001）. Although no correlations with clinicopathological features, PinX1 downregulation was significantly associated with adverse 5-year overall survival （OS） and disease-free survival （DFS）.Conclusion PinX1 protein expression is decreased in CRC, which may be a new promising tumor marker for CRC prognosis and 5-FU chemosensitivity.
出处
《中华临床医师杂志（电子版）》
CAS
2015年第17期45-47,共3页
Chinese Journal of Clinicians(Electronic Edition)
基金
皖南医学院中青年科研基金(WK201035F)
