间充质干细胞治疗原发性干燥综合征的研究进展

Research advancement of mesenchymal stem cells in the treatment of primary Sj?gren syndrome

干燥综合征是一种侵犯外分泌腺,累及多脏器、多系统,以高度淋巴细胞浸润为特征的慢性炎症性自身免疫性疾病。目前发病机制尚未明确,治疗仍停留在改善症状,提高患者生存质量,阻止疾病进展阶段,尚无根治性方法。近年来间充质干细胞作为治疗自身免疫性疾病的一种新方法已成为研究热点,本文就间充质干细胞与自身免疫性疾病及治疗原发性干燥综合征的相关研究进展进行综述。

Sjogren syndrome is a kind of chronic inflammatory autoimmune disease, characterized by a large number of lymphocytic infiltration of exocrine glands, which can effect multiple organs and systems. The pathogenesis of Sj？gren syndrome is not clear. At present the disease just can be treated by improving the symptom and the quality of survival and preventing the progress of disease instead of being cured radically. In recent years, it has been a hot spot of research that mesenchymal stem cells as a new way to treat autoimmune disease. The paper made a review to state research advancement of the link between mesenchymal stem cells and autoimmune disease, especially primary Sj？gren syndrome.