脑梗死患者急性期外周血白细胞及亚型细胞变化

Characteristics of Peripheral Leukocyte and Subtype Cells in Acute Phage of Cerebral Infarction Patients

目的:探讨急性脑梗死患者发病24 h内外周血白细胞及亚型细胞的变化特点。方法:急性脑梗死患者96例,统计其外周血白细胞及其亚型细胞变化,并记录美国国立卫生研究院卒中量表(NIHSS)评分,DWI测定脑梗死体积,利用受试者工作特征(ROC)曲线及Logistic回归分析模型进行统计。结果:脑梗死急性期外周血中性粒细胞升高相比白细胞总数升高及淋巴细胞减低更为明显(P<0.05),且发病时间≥3.5 h、NIHSS评分≥3.5分与外周血中性粒细胞升高明显相关(P<0.05)。结论:脑梗死初期外周血中性粒细胞升高可能有助于推测脑梗死可能的发生时间及严重程度。

Objective： To investigate the dynamic changes of peripheral total leukocytes, and subtype cells in patients with stroke onset within 24 h. Methods： Ninty-six patients diagnosed as newly onset of cerebral infarction were enrolled. The clinical data including the counts of the total leukocytes and the subtypes in peripheral blood, NIHSS score, and the infarction volume in DWI were analyzed. The potential factors involved in the changes of pe-ripheral blood leukocytes were analyzed by Logistic regression analysis and receiver operating characteristic （ROC） curves. Results： The abnormal rising of the counts of neutrophils in peripheral blood was more remarkably than that of the total leokocytes and the lymphocytes （P＆lt;0.05）. The time of stroke onset ≥3.5 h and the NIHSS score≥3.5 may be the main risk factors of the abnormal increase of neutrophils （P＆lt;0.05） in peripheral blood within 24 h after stroke onset. Conclusion： The increase of peripheral blood neutrophils in the early stage of cerebral infarction may be helpful to evaluate the duration and severity of cerebral infarction.