miR-126在宫颈癌组织中的表达及其临床意义

Expression of miR-126 in cervical cancer and its clinical significance

目的研究mi R-126在宫颈癌组织中的表达并探讨其临床意义。方法收集宫颈癌组织标本78例。采用q RT-PCR技术检测宫颈癌组织及癌旁正常宫颈组织中mi R-126的表达情况,并分析mi R-126在宫颈癌组织中的表达水平与宫颈癌患者临床病理参数之间的关系。结果 mi R-126在宫颈癌组织中的表达相对于癌旁正常宫颈组织中的表达明显下调（P〈0.001）。mi R-126在宫颈癌组织中的高表达率与宫颈癌患者的组织分化程度、淋巴结转移以及临床分期明显相关,即mi R-126在低分化组的高表达率明显低于高中分化组（P=0.013）,在有淋巴结转移组的高表达率明显低于无淋巴结转移组（P=0.005）,在Ⅲ~Ⅳ期组中的高表达率明显低于Ⅰ~Ⅱ期（P=0.007）。而mi R-126在宫颈癌组织中的高表达率在不同年龄、肿瘤大小、HPV感染患者组之间比较差异均无统计学意义（P〉0.05）。结论 mi R-126可能参与宫颈癌的发生发展,检测mi R-126的在宫颈癌中的表达对预测宫颈癌的浸润转移具有重要意义。

Objective To investigate the expression of miR-126 in cervical cancer and its clinical signifi-cance. Methods Expression of miR-126 was detected in 78 cases of cervical cancer by qRT-PCR. The correlations of miR-126 expression with clinicopathologic characteristics of cervical cancer patients were analyzed. Results The expression of miR-126 were significantly down-regulated in cervical cancer tissues than in the adjacent normal tis-sues. The difference was statistically significant （P〈0.001）. Decreased miR-126 expression in cervical cancer was found to be significantly associated with histological grade （P=0.013）, lymph node metastasis （P=0.005）, and the FI-GO stage （P=0.007）. However, there was no statistically significant difference between the expression and age, tumor size, as well as HPV infection （P〉0.05）. Conclusion The expression of miR-126 may be involved in the occurrence and development of cervical cancer. Detection of miR-126 expression in cervical cancer is of great importance in the prediction of invasion and metastasis.