小牛血去蛋白提取物眼用凝胶与玻璃酸钠滴眼液防治LASIK术后干眼疗效分析

Clinical effect of rotein-free calf blood extract eye gel and sodium hyaluronate eye drops in the prevention and treatment of dry eye after laser-assisted in situ keratomileusis

目的比较小牛血去蛋白提取物眼用凝胶与玻璃酸钠滴眼液防治准分子激光原位角膜磨镶术(LASIK)后干眼的临床疗效。方法选取2011年6月至2014年6月于我院就诊的拟行LASIK的近视患者160例(320眼),将其随机分为A组与B组各80例(160眼),其中A组术后使用小牛血去蛋白提取物眼用凝胶治疗,B组使用玻璃酸钠滴眼液治疗。用药前与用药后4周进行干眼主观症状评分、泪膜破裂时间(BUT)、泪液分泌试验(SchirmerⅠ)及角膜荧光素染色检查,评价两组治疗效果。结果治疗4周后,A组临床治疗总有效率为91.25%,较B组的73.75%明显提高,两组间比较差异具有统计学意义(P<0.05);治疗4周后两组患者除泪液分泌试验比较差异无统计学意义(P>0.05)外,A组症状评分明显低于B组,泪腺破裂时间明显长于B组,角膜荧光素染色评分明显低于B组,经比较差异均具有统计学意义(P<0.05)。结论在防治LASIK术后干眼方面,小牛血去蛋白提取物眼用凝胶较玻璃酸钠滴眼液临床效果更优,值得临床应用。

Objective To explore the clinical effect of protein-free calf blood extract eye gel and sodium hy-aluronate eye drops in the prevention and treatment of dry eye after laser-assisted in situ keratomileusis （LASIK）. Methods One hundred and sixty patients （320 eyes） undergoing LASIK in our hospital from June 2011 to June 2014 were selected and then divided them into group A and group B, with 80 patients （160 eyes） in each group. Patients in group A were treated with protein-free calf blood extract eye gel, while patients in the group B were treated with sodi-um hyaluronate eye drops. Before treatment and after 4 weeks of treatment, subjective dry eye symptom scores, tear break-up time （BUT）, SchirmerⅠtest and corneal fluorescein staining were observed and compared to evaluate the clinical effect of the two groups. Results After 4 weeks of treatment, the total effective rate in group A was 91.25%, significantly higher than 73.75%in group B （P〈0.05）. There was no significant difference in SchirmerⅠtest between the two groups after treatment （P〉0.05）, but the subjective dry eye symptom scores of group A was sig-nificantly lower, with the BUT significantly longer and the score of corneal fluorescein staining significantly lower （P〈0.05）. Conclusion In the prevention and treatment of dry eye after LASIK, the clinical effect of protein-free calf blood extract eye gel is better than sodium hyaluronate eye drops, which is worthy of further clinical application.