伴有牙周炎的IgA肾病患者牙周治疗前后血清TNF-α与IL-8变化分析

Changes in levels of serum TNF-α and IL-8 before and after periodontal therapy for patients of Ig A nephropathy with periodontitis

目的观察伴有慢性牙周炎的Ig A肾病患者牙周治疗前后血清肿瘤坏死因子-α(TNF-α)和白细胞介素-8(IL-8)变化。方法选取伴有慢性牙周炎的Ig A肾病患者50例(治疗组)和健康者30例(对照组)。对照组不予特殊处理,治疗组采用超声洁牙和VECTOR牙周治疗仪进行牙周治疗,对照组于初诊时,治疗组于治疗前及治疗后4周,分别检测两组受试者的牙周指数和血清TNF-α与IL-8的浓度。血清中TNF-α与IL-8的浓度采用酶联免疫吸附法测定。结果治疗组患者经过牙周治疗后,牙周状况明显好转,血清TNF-α与IL-8浓度与治疗前比较均明显降低,差异均有统计学意义(P<0.05),但是牙周指数、TNF-α和IL-8浓度仍高于对照组,差异均有统计学意义(P<0.05)。结论牙周治疗不仅可以有效改善牙周组织的病变,利于牙周炎的恢复,而且可降低血清中细胞因子TNF-α、IL-8的水平,有助于对Ig A肾病患者肾病的治疗。

Objective To examine the levels of serum tumor necrosis factor-α（TNF-α） and interleukin-8 （IL-8） for IgA nephropathy patients with periodontitis before and after periodontal therapy. Methods Fifty pa-tients of IgA nephropathy with chronic periodontitis （study group） and 30 healthy individuals （control group） were in-cluded in this study. The study group was treated by ultrasonic and VECTOR periodontal therapy apparatus, whereas the control group received no special treatment. We measured the periodontal indexes, and serum TNF-αand IL-8 lev-els by enzyme-linked immunosorbent assay （ELISA） at the visit of doctor in the control group as well as before treat-ment and 4 weeks after treatment in the study group. Results After periodontal therapy, the periodontal status was significantly improved, with the levels of periodontal indexes and serum TNF-α and IL-8 significantly decreased. Compared with the control group, the periodontal indexes and the serum TNF-αand IL-8 were still significantly higher. Conclusion Periodontal treatment can not only effectively improve the periodontal lesions and promote the recovery of periodontitis, but also reduce the levels of serum TNF-αand IL-8 and benefit the treatment for IgA nephropathy.