肾康颗粒治疗慢性肾功能衰竭临床观察

Clinical Observation of Shenkang Granules with Western Medicine on Chronic Renal Failure

目的:观察肾康颗粒治疗瘀血阻滞型慢性肾衰竭(CRF)患者的临床疗效及其对血清瘦素(Leptin)的影响。方法:选择符合CRF前3期诊断标准且辨证为瘀血阻滞型病例60例,按随机化原则分为治疗组29例和对照组31例;治疗组给予肾康颗粒+西药对症治疗,对照组给予单纯西药对症治疗。比较两组惠者治疗前后血清Leptin、肾功能、中医临床证候积分等指标。并选择30例健康体检者及60例CRF患者治疗前血清Leptin水平为对照。结果:治疗组临床总有效率86.21%,对照组总有效率35.48%,两组比较有显著差异(P<0.01)。60例CRF患者治疗前血清Leptin水平较健康对照组明显升高(P<0.01);同组治疗前后比较,对照组血清Leptin水平无显著性差异(P>0.05),而治疗组血清Leptin水平明显下降(P<0.01);两组治疗前后差值组间比较,治疗组降低Leptin作用优于对照组(P<0.01);治疗组Scr、BUN水平治疗前后有显著性降低(均P<0.01),Ccr有显著性升高(P<0.01)。结论:瘀血阻滞型CRF患者血清Leptin水平较健康人明显升高;肾康颗粒具有降低血清Leptin水平、改善肾功能、改善临床症状的作用。

Objective ： To observe the clinical efficacy of shenkang granules on patients with chronic renal failure （CRF） typed stagnation of blood stasis, and to explore the influence of shenkang granules on serum leptin . Methods： 60 cases of patients who fit the previous three periods CRF diagnostic standard and typed stagnation of blood stasis were selected. According to randomization, they were divided into treatment group with 29 cases and control group with 31 cases. The treatment group was given shenkang granules with western symptomatic treatment, and the control group was given simple symptomatic treatment with western medicine ; the serum leptin, renal func- tion, and clinical symptomatic scores of TCM before and after treatment between the two groups were compared ; 30 cases of healthy persons were selected as the healthy control group, their serum leptin levels were compared with 60 patients with CRF before treatment. Results： The total effective rate was 86.21% in treatment group ,while in the control group was 35.48 %. Comparing between the two groups, the difference had statistical signifecance （ P 〈 0. 01 ）. Before treatment, the serum leptin levels of 60 cases patients with CRF were significantly higher than that of healthy control group（ P 〈 0.01 ）. Comparing serum leptin levels before and after treatment, the control group had no significant difference （P 〉 0.05）. Comparing the same group before and after treatment, the levels of Scr and BUN in the treatment group decreased significantly（P 〈0. 01 ）, Ccr significantly rised （P 〈0. 01 ）. Conclusion ： the Serum leptin levels in patients with CRF typed stagnation of blood stasis were significantly higher than the healthy persons; Shenkang Granules can decrease levels of serum leptin, improve renal function and the clinical symptoms in patients with CRF typed stagnation of blood stasis.