基于脑默认模式网络研究针刺得气客观化的思路探讨

Discussion on the Objectified Study of Qi-Arrival of Acupuncture based on Mental DefaultMode Network

针刺得气的描述主要强调医者和患者的主观感受,得气与否大多依靠医者经验把握,具有明显的主观性和随意性,不便于针刺疗效机制的阐述和相关研究的开展。笔者提出"针刺得气的脑中枢效应与脑默认模式网络密切相关"的假说,运用静息态功能性磁共振成像技术,在生理和病理状态下,观察以内关穴为中心,本经配穴、同名经配穴、表里经配穴、非穴配穴等不同穴位配伍情况下,针刺得气后脑功能区的激活情况,分析针刺得气激活脑区和脑默认模式网络的关联、激活脑区和与腧穴疗效相关脑区的关联,探索针刺得气的物质基础及其作用机制,为针刺得气客观化研究提供思路,为科学阐述针刺疗效机制奠定基础。

The description of qi-arrival of acupuncture in Traditional Chinese Medicine mainly emphasizes the subjective experience of patients and doctors. Depending on the experience of doctors mostly, the qi-arrival of acu- puncture is subjective and arbitrary, so it is unfavorable to explain the curative mechanism of acupuncture and launch related study. This paper put forward a hypothesis that the effect of qi-arrival of acupuncture in brain cen- ters was closely related to mental default-mode network. In physiological and pathological state, applying resting functional magnetic resonance imaging to observe the activated status of qi-arrival in brain under circumstances of nei guan centered with different combination acupoints as combination of same-meridian acupoints, combination of common-meridian acupoints and combination of exterior-interior meridian acupoints. To explore the material basis and mechanism by analyzing the relationship between brain centers of qi-arrival of acupuncture and mental defaultmode network, and the relationship between activated brain area and efficacy related aeupoints, in an attempt to provide referred idea for objectifying qi-arrival of acupuncture