两种化疗方案对晚期宫颈癌的疗效观察

Clinical effects of two chemotherapy regimens on advanced cervical cancer

目的探究顺铂分别与多西它赛和紫杉醇联合对晚期宫颈癌的临床疗效。方法选取我院收治的80例局部晚期宫颈癌患者,采取随机数字表法将其分成A、B组,每组40例。A组患者采用多西它赛75mg/m2+顺铂50 mg/m2,B组患者采用紫杉醇60 mg/m2+顺铂50 mg/m2,分别化疗l^2个疗程,化疗间隔时间均为21 d,观察与比较2组患者经不同治疗方法后的临床疗效及不良反应等情况。结果 A、B组患者经不同用药方式后,疗效差异无统计学意义(P>0.05)。B组患者出现不良反应的例数明显高于A组患者,差异有统计学意义(P<0.05)。结论多西它赛75 mg/m2联合顺铂50 mg/m2对晚期宫颈癌临床作用显著,且不良反应较少,安全性高。

Objective To investigate the clinical effects of Cisplatin combined with Docetaxel versus Cy-clophosphamide on advanced cervical cancer. Methods Eighty patients with locally advanced cervical cancer hospi-talized in our hospital were included as the subjects in the study, and were divided into groups A and B randomly （ n=40 each）. Group A received Docetaxel 75 mg/m2 and Cisplatin 50 mg/m2, while group B received Paclitaxel 60 mg/m2 and Cisplatin 50 mg/m2, with 1 to 2 courses of chemotherapies and an interval of 21 d. The clinical effects and ad-verse reactions of the two chemotherapies were determined and compared between the two groups of patients. Results There was no statistically significant difference in the effect between groups A and B after received different medica-tion （P〉0.05）. The number of patients with adverse reactions in group B was significantly higher than that in group A, with statistically significant difference （P〈0.05）. Conclusion Docetaxel 75 mg/m2 and Cisplatin 50 mg/m2 have sig-nificantly clinical effects on advanced cervical cancer, with less adverse reactions and high safety.