球晶造粒法制备硝苯地平缓释微球

Preparation of nifedipine sustained-release microspheres by Spherulite granulation

目的 考察硝苯地平缓释微球的制备工艺及其体外释放度.方法 以邻苯二甲酸羟丙甲纤维素酯（HP55）为载体材料,采用球晶造粒技术制备硝苯地平缓释微球.考察硝苯地平微球的粒径、形态、载药量、包封率及体外释放度.结果 所得微球外观圆整度好,粒径分布在70~150μm,载药量为18.91%,包封率为94.95%.结论 该法可用于硝苯地平缓释微球的制备.

Objective To investigate the preparation and releasing rate of nifedipine sustained-release micro-spheres. Methods HP55 was used as the carrier material, and the nifedipine sustained-release microspheres were prepared by Spherulite granulation. The particle size, morphology, drug loading, encapsulation efficiency and releasing rate in vitro were investigated. Results The microspheres were spherical in appearance. The particle size, drug load-ing and encapsulation efficiency of the microspheres was 70~150 μm, 18.91%, and 94.95%, respectively. Conclusion Spherulite granulation is suitable for preparing nifedipine sustained-release microspheres.