女性泌尿生殖道支原体感染情况及药敏分析

Analysis on mycoplasma infection and drug sensitivity of female urogenital tract

目的了解武警新疆总队医院妇科门诊患者生殖道支原体的感染情况及药敏试验结果,为临床合理用药提供实验室依据。方法采用支原体分离培养药敏试剂盒对1 067份妇科门诊患者的生殖道分泌物标本进行支原体鉴定及药物敏感分析。结果 1 067份标本中,检测出支原体阳性标本659份,其中解脲脲原体(Uu)阳性占72.99%(481/659),人型支原体(Mh)阳性占3.79%(25/659),Uu与Mh混合阳性占23.22%(153/659),对12种抗菌药物的药敏结果显示,单一感染Uu较敏感的药物有交沙霉素、强力霉素、美满霉素、四环素、克拉霉素、阿奇霉素、罗红霉素;单一感染Mh较敏感的药物有强力霉素、交沙霉素、美满霉素、四环素;Uu与Mh混合感染较敏感的药物有交沙霉素、美满霉素、强力霉素。结论该院支原体感染主要以Uu感染为主,不论是单一Uu感染还是Uu与Mh混合感染,在抗菌药物的敏感性上都有差异,临床医生应根据患者情况依照药敏结果合理选择抗菌药物,降低耐药率。

Objective To investigate the incidence and the drug-sensitivity results of mycoplasma infection in genital tract from the gynecological outpatients,in order to provide a laboratory evidence for clinical rational use of drug. Methods The drug sensitiv ity kit was used for isolation and culture of mycoplasma, reproductive tract secretions samples of 1 067 cases of gynecological pa tients were collected to do mycoplasma identification and drug sensitivity test. Results In 1 067 samples,the positive rate of myco plasma were 659 samples,including ureaplasma urealyticum（Uu） positive rate was 72.99% （481/659）,mycoplasma hominis （Mh） positive rate was 3.79% （25/659）,Uu and Mh positive rate accounted for 23.22% （153/659）. The drug sensitivity results of 12 kinds of antimierobial agents showed that single infection Uu was more sensitive to josamycin,doxycycline, minocycline, tetracy cline, clarithromycin, azithromycin and roxithromycin. Single infection Mh was more sensitive to doxycycline,josamycin, minocycline and tetracycline. Mixed infection of Uu and Mh was more sensitive to josamycin, minocycline and doxycycline. Conclusion The main pathogen isolated from patients infected with plasma in our hospital is Uu, whether single Uu or Uu, Mh mixed infection, there are differences in the sensitivity of antimicrobial, clinicians should use drug rationally according to the conditions of patients and drug sensitivity results to reduce drug resistance rate.