中国内陆地区恶性肿瘤家族史与胃癌发病风险的meta分析

Relationship between family history of malignant tumor and onset risk of gastric cancer in inland China: A meta-analysis

目的研究我国恶性肿瘤家族史与胃癌发病风险的关系和关联强度,为构建中国内陆地区胃癌发病风险评估模型提供数据支持。方法通过中国知网、万方数据和维普数据检索2000-2015年国内有关恶性肿瘤家族史与胃癌发病关系的文献资料,采用meta分析方法对其进行定量综合分析,计算合并比值比OR及其95%CI。结果综合18篇文献结果,得出胃癌家族史与胃癌发病关系的合并OR值为3.25(95%CI:2.48-4.27),恶性肿瘤家族史与胃癌发病关系的合并OR值为1.37(95%CI:1.18-1.59)。结论恶性肿瘤家族史增加胃癌发病风险,其中胃癌家族史高于整体肿瘤的风险,对于有胃癌家族史人群定期体检非常重要。

Objective To explore the relationship and strength of association between family history of malignant tumor and the onset risk of gastric cancer in inland China for providing the data support for constructing the onset risk model of gastric cancer. Methods A meta-analysis was used to quantitatively analyze the literatures searched from CNKI, Wangfa data and VIP. These literatures were published from 2000 to 2015, involving the relationship between the family history and the onset of gastric cancer, and OR value and 95 % CI value were enrolled. Results A total of 18 literatures were enrolled. OR value of the family history of gastric cancer and the onset risk of gastric caner was 3.25（95% CI： 2.48 -4.27）, while OR value of family history of malignant tumor and onset risk of cancer was 1.37 （95% CI： 1.18 - 1.59）. Conclusion Family history of malignant tumor increases the onset risk of gastric cancer, while cases of family history of gastric cancer have higher risk than that of other tumors. It is important for cases of family history of gas- tric cancer to take physical examination regularly.