细菌素的抗细菌耐药研究及应用现状

Study and application of bacteriocin against bacterial resistance

随着青霉素等抗生素的问世,人类因细菌感染所致疾病的死亡率大为降低;但在抗生素广泛应用至今,我们又面临着细菌耐药日趋严重、耐药菌感染难以控制、新抗生素研发脚步迟滞的严峻局势。如何应对这一全球性的难题,研究者们殚精竭虑,力求在抗生素以外寻求新的突破,有着比抗生素更悠久历史、同样具有抗菌活性的细菌素引起了研究者们的重视。但抗菌谱、产量等问题使细菌素的应用受到了限制,打破瓶颈成了当下研究的热点。本文主要对细菌素的研究现状、应用及异源表达做了相关综述。

With the advent of antibiotics such as penicillin, the mortality from bacterial infection has been greatly reduced. But decades later, after widespread application of antibiotics, we should deal with the severe situation that the antibiotic re-sistance is becoming increasingly serious, the infections from resistant strains are difficult to control and development of new antibiotics is rather slow.In order to overcome these problems, researchers are exploring new ways besides antibiotics, and pay more attentions to bacteriocins because of their antibacterial activities.But the applications of bacteriocins are also re-stricted by antibacterial spectrum, production and so on, and making a breakthrough becomes a hotspot.This review will focus on the status, application and heterologous expression of bacteriocins.