重叠综合征患者血清ApoB/ApoA1检测意义及其与心脑血管事件发生率的相关性

RELATIONSHIP BETWEEN SERUM APOB/APOA1 RATIO AND INCIDENCE OF CARDIOVASCULAR AND CEREBROVASCULAR EVENTS IN OSAHS-COPD PATIENTS

目的观察血清载脂蛋白B/载脂蛋白A1(ApoB/ApoA1)比值与不同病情严重程度的OSAHSCOPD重叠综合征(OS)患者的关系,了解ApoB/ApoA1与OS患者心脑血管事件发生率的相关情况。方法选取健康对照组40例,OS患者140例,根据AHI及末梢血氧饱和度情况,分为轻、中度、重度OS组,检测患者血清中ApoA1、B水平,计算ApoB/ApoA1比值,分析血ApoB/ApoA1比值与OS患者的关系,了解其检测ApoB/ApoA1与OS患者心脑血管事件发生率的相关;根据患者既往病史,将患者分为合并心脑血管疾病组与不合并心脑血管疾病组,了解ApoB/ApoA1与OS患者心脑血管事件发生率的相关性。结果与健康对照组相比,OS组ApoB/ApoA1比值水平明显升高(P<0.05);与轻度OS组相比,中、重度OS组ApoB/ApoA1比值水平升高(P<0.05);与中度OS组比较,重度组ApoB/ApoA1比值水平升高(P<0.05);OS组合并心脑血管疾病组与不合并组患者血清指标比较,合并心脑血管疾病组ApoB/ApoA1比值水平升高(P<0.05)。结论 OS患者血脂代谢异常的严重程度和其病情严重程度相关,并且与OS患者心脑血管事件发生率的相关。

Objective To explore the relationship between serum apoB/apoA1 ratio and the incidence of cardiovascular and cerebrovascular events in OSAHSCOPD patients. Methods A healthy control group was selected from 40 cases, according to the AHI and peripheral blood oxygen saturation, 140 overlap syndrome （OS） cases were divided into mild, moderate and severe OS group. The level of apoB and apoA1 was detected in serum of patients, apoB/apoA1 ratio was calculated, and the relationship between apoB/apoA1 ratio and OS patients was analyzed. To understand the the relevance between apoB/apoA1 and the incidence of cardiovascular and cerebrovascular events in patients with OS, according to the patients past history, the patients were divided into two groups, patients with cardiovascular and cerebrovascular diseases group, and does not merge cardiovascular disease group, to understand the the relevance between apoB/apoA1 and the incidence of cardiovascular and cerebrovascular events in patients with OS. Results Compared with the healthy control group, the OS group apoB/apoA1 ratio of level of increased was significantly （P〈0. 05） ; compared with mild OS group, moderate and severe OS group apoB/apoA1 ratio was elevated （P〈0.05） ; compared with moderate OS group, severe group apoB/apoA1 ratio increased （P〈0.05）. In case group, comparison of serum indexes in cardiovascular and cerebrovascular diseases group and does not merge cardb ovascular disease group, the apoB/apoA1 ratio of combined cardiovascular and eerebrovascular diseasegroup was increased （P〈0.05）. Conclusion The severity of abnormal lipid metabolism in patients with OS is correlated with the severity of the disease, and is correlation with the incidence of cardiovascular and cerebrovascular events in patients with OS.