线粒体动态变化参与线粒体自噬介导运动适应的研究进展

Research Progress of Mitochondrial Dynamics Involving in Mitophagy Mediating Adaptation to Exercise

对近年线粒体动态变化和线粒体自噬的研究进行分析发现:线粒体自噬是介导运动适应的重要机制,而泛素-蛋白酶体系统连接了线粒体动态变化和线粒体自噬,在此过程中,E3泛素化连接酶是关键分子,对于维持骨骼肌稳态有重要意义,但具体参与其中的分子及其机制有待进一步探讨。

This paper analyzed the research on mitochondrial dynamics and mitophagy. The results find that mitophagy is an important mechanism of mediating adaptation to exercise, and the ubiquitin-proteasome system connects the mitochondrial dynamics with mitophagy. The E3 ubiquitin ligase is a key molecule during the whole process. It plays an important role in maintaining skeletal muscle homeostasis, but the specific molecules and mechanism need to be further studied.