摘要
对近年线粒体动态变化和线粒体自噬的研究进行分析发现:线粒体自噬是介导运动适应的重要机制,而泛素-蛋白酶体系统连接了线粒体动态变化和线粒体自噬,在此过程中,E3泛素化连接酶是关键分子,对于维持骨骼肌稳态有重要意义,但具体参与其中的分子及其机制有待进一步探讨。
This paper analyzed the research on mitochondrial dynamics and mitophagy. The results find that mitophagy is an important mechanism of mediating adaptation to exercise, and the ubiquitin-proteasome system connects the mitochondrial dynamics with mitophagy. The E3 ubiquitin ligase is a key molecule during the whole process. It plays an important role in maintaining skeletal muscle homeostasis, but the specific molecules and mechanism need to be further studied.
出处
《上海体育学院学报》
CSSCI
北大核心
2015年第5期47-52,共6页
Journal of Shanghai University of Sport
基金
国家自然科学基金资助项目(31171142)
青少年健康评价与运动干预教育部重点实验室建设项目(4050054123514203/004)