维生素D及其受体抗肝癌作用研究进展

Cross-talk between vitamin D and its receptors in hepatocellular carcinogenesis

肝癌具有生存期短、病死率高及发病隐匿等特点,目前仍是慢性病毒性肝炎和肝硬化患者的主要死亡原因。近年研究发现,维生素D可通过与其受体结合而抑制细胞增殖、诱导细胞凋亡和分化,从而发挥抗肿瘤作用。本文简要综述了近年有关维生素D及其受体结合抑制肝癌发生发展的作用机制及维生素D受体基因多态性、维生素D类似物与肝癌发生发展的关系研究进展,以期为肝癌的治疗提供临床依据。

Hepatocellular carcinoma （HCC） is the main cause of death in patients with chronic viral hepatitis and cir-rhosis,which is characterized by hidden onset,short lifetime and high mortality. It was recently identified that vitamin D,binding with its receptor,may play an important role in anti-tumor effects by inhibiting cell proliferation and inducing cell apoptosis and differentiation. This paper mainly reviewed the recent studies on mechanism of vitamin D and its receptor in inhibiting carcino-genesis,as well as the relationship between vitamin D receptor gene polymorphism and vitamin D analogue in patients with HCC,in order to provide clinical application in the treatment of HCC.