CT在难治性癫痫治疗中的综合应用

Comprehensive application of CT in treatment of refractory epilepsy

目的探讨CT在难治性癫痫治疗中的应用。方法将1189例癫痫患者均应用常规的抗癫痫药物系统治疗6个月,将其中符合难治性癫痫诊断的160例,从中随机选取80例患者全部进行CT螺旋扫描,依据CT扫描结果,将CT阳性结果的患者分为A组,阴性患者分为B组,其余80例患者作为C组。A、B两组患者除继续应用常规一线抗癫痫药物治疗外,均联合应用其他不同的治疗方法,其中A组患者辅助低频重复经颅刺激和维生素E治疗,B组患者则加服中药及维生素E治疗,C组继续应用常规一线抗癫痫药物治疗。12个月后再对三组患者的疗效进行评估。结果 A、B两组患者经过12个月的联合治疗,A组的有效率为74.6%,B组的有效率80.0%,与联合治疗前疗效有较明显的提高。C组的有效率为40.0%。结论 CT在探讨难治性癫痫的病因中有着重要作用,对其治疗方案的制定起着重要的指导作用。

Objective To evaluate the application value of CT in the treatment of refractory epilepsy. Methods 1189 patients with epilepsy were given conventional antiepileptic drug systematic treatment for 6 months. Among them, 160 patients met the refractory epilepsy diagnosis, of which 80 patients were randomly selected to receive CT spiral scanning, and based on the CT scanning results, the patients with positive CT results were assigned to group A and those with negative CT results were assigned to group B, and the rest 80 patients were assigned to group C. In addition to the continuous application of conventional first-line antiepileptic drugs, both group A and group B were given the combined application of other different treatment methods. Group A was assisted with low frequency repetitive transcranial stimulation and vitamin E treatment; group B was given additional oral administration of traditional Chinese medicine and vitamin E treatment; group C was given the continuous application of conventional first-line antiepileptic drugs.Twelve months later, efficacy of the three groups was evaluated. Results After 12 months of combined treatment, the effective rate of group A was 74.6% and that of group B was 80.0%, and the efficacy of both groups improved significantly compared to that before the combination treatment. The effective rate of group C was 40.0%. Conclusion CT plays an important role in ascertaining the pathogenesis of refractory epilepsy and has important guiding effect on the development of treatment programs.