内镜黏膜下剥离术治疗早期胃癌临床疗效分析

The clinical efficacy of endoscopic submucosal dissection in treatment of early gastric cancer

目的分析内镜黏膜下剥离术治疗早期胃癌的疗效。方法选取我院2013年4月~2014年11月治疗的106例EGC患者进行研究,将其分为ESD组和EMR组,比较两组手术时间、出血量及住院时间、病灶切除效果、复发率。结果 ESD组手术操作时间长于EMR组（P〈0.05）,EMR组的手术出血量多于ESD组,但两组的出血量比较差异无统计学意义（P〉0.05）;两组住院时间比较差异无统计学意义（P〉0.05）。ESD组中治愈切除、完全切除、大块切除率均高于EMR组,两组病灶切除率比较差异有统计学意义（P〈0.05）;ESD组患者在术后半年内的复发率低于EMR组（13.21%vs 1.89%,P〈0.05）。结论应用ESD术治疗EGC可明显提高临床疗效。

Objective To analyze the clinical effect of endoscopic submucosal dissection in treatment of early gastric cancer. Methods From April 2013 to November 2014, 106 EGC patients were randomly divided into ESD group and EMR group, the operating time, amount of bleeding, and hospitalization time, lesion resection, recurrence rate were compared between two groups. Results The operation time in ESD group was longer than the EMR group（P〈0.05）, the amount of bleeding in EMR group was more than the ESD group, but there was no significant difference（P〉0.05）; The hospitalization time of two groups had no significant difference（P〉0.05）. The curative resection, total resection, large resection number in ESD group were significantly higher than that of the EMR group, there was significant difference between two groups（P〈0.05）; The recurrence rate in ESD group was lower than that of EMR group after surgery six months（13.21% vs 1.89%, P〈0.05）. Conclusion The endoscopic submucosal dissection in treatment of early gastric cancer can improve obviously the clinical effect.