放疗与榄香烯注射液联合治疗原发性肝癌的效果评价

Clinical observation of elemene injection adjuvant three-dimensional con-formal radiotherapy in treatment of primary hepatic cancer

目的观察榄香烯注射液联合放疗治疗原发性肝癌疗效及对血清中基质金属蛋白酶(MMP)-2和MMP-9的影响。方法将我院收治的100例原发性肝癌患者随机分为对照组和观察组,每组50例。采用常规放疗方式对对照组患者实施治疗;观察组在上述基础上放疗第1天开始予揽香烯注射液600 mg/d,直至放疗结束。统计两组治疗总有效率,并观察治疗前后血清MMP-2和MMP-9变化。结果观察组的治疗总有效率达92%,明显高于对照组的72%(P<0.05),观察组治疗前后MMP-2和MMP-9血清浓度分别下降为(89.36±11.03)ng/L和(85.28±8.32)ng/L,显著高于对照组的(46.28±10.12)ng/L和(39.66±9.43)ng/L(P<0.05),观察组的放疗计划实施时间和住院接受治疗总时间分别为(14.53±3.08)d和(21.67±3.54)d,明显短于对照组的(25.43±5.20)d和(35.41±6.56)d,差异有统计学意义(P<0.05)。结论应用榄香烯注射液与放疗方式联合对原发性肝癌患者实施治疗的临床效果明显,并能有效下调血清中MMP-2和MMP-9表达,对抑制肿瘤进展有重要作用。

Objective To observe the clinical efficacy of the elemene injection adjuvant three-dimensional conformal radiotherapy to treat the primary liver cancer and their impact to the expression of serum matrix metalloproteinase（MMP）-2 and MMP-9. Methods One hundred primary liver cancer patients were randomly divided into the observation group which was given elemene injection（600 mg/d） adjuvant three-dimensional conformal radiotherapy and the control group which was given three-dimensional conformal radiotherapy in our hospital, with an average 50 cases in each group. The control group was treated with the three-dimensional conformal radiotherapy, while the observation group was given elemene injection（600 mg/d） based on the control group, until the end of radiotherapy. The total efficiency of the two groups and the change of serum MMP-2 and MMP-9 before and after treatment were observed. Results The total efficien cy of the observation group was reach to 92%, which was significantly higher than the control group that was only 72%（P〈0.05）. In addition, the decreased changes of the serum MMP-2 and MMP-9 in the observation group were（89.36±11.03） ng/L and（ 85. 28 ± 8. 32） ng / L respectively, which were also significantly higher than the control group which were（46.28 ±10.12） ng/L and（39.66±9.43） ng/L（P〈0.05）. However, the total time for radiotherapy treatment and hospitalization time in the observation group were（14.53 ±3.08）d and（21.67±3.54）d respectively, which was significantly shorter than the control group which were（ 25. 43 ± 5. 20） d and（ 35. 41 ± 6. 56） d respectively（P〈0.05）.Conclusion The clinical efficacy of the elemene injection adjuvant three-dimensional conformal radiotherapy in treatment of primary liver cancer is obvious. And it can reduce the expression of MMP-2 and MMP-9 in serum effectively, which have an important role to inhibit the tumor progression.