急性缺血性脑卒中患者治疗前血浆和肽素水平与近期预后的相关性研究

Correlation between plasma copeptin level before treatment and recent prognosis in patients with acute ischemic stroke

目的：探讨急性缺血性脑卒中患者治疗前血浆和肽素水平与近期预后的相关性。方法随机选取深圳市第二人民医院2013年6～9月的急性缺血性脑卒中患者100例作为试验组，50例健康体检者为对照组，测定两组治疗前与治疗30 d后的血浆和肽素水平，用健康调查简表（ SF-36）及美国国立卫生研究院卒中量表（ NIHSS）的降低率评估30 d后的近期预后情况。运用SPSS 20.0软件包处理数据。结果治疗前试验组的血浆和肽素水平明显高于对照组[（439.03±210.91） pg／ml vs．（54.91±18.65）pg／ml，t＝2.873，P＜0.01]。 NIHSS结果：治疗前血浆和肽素水平越高，NIHSS降低率越小，甚至出现NIHSS值升高情况，试验组根据减少的NIHSS评分的百分数分为5个亚组，各亚组预后情况与患者治疗前和肽素水平呈负相关（ r值分别为－0.661、－0.587、－0.734、－0.684、－0.632，均P＜0.001）。 SF-36结果：预后情况与患者治疗前和肽素水平呈负相关（ r 值分别为－0.673、－0.661、－0.715、－0.587、－0.734、－0.687、－0.635、－0.703，均P＜0.001）。结论急性缺血性脑卒中患者治疗前的血浆和肽素水平越高，近期预后越差。

Objective To explore the correlation between plasma copeptin level before treatment and recent prognosis in patients with acute ischemic stroke .Methods One hundred patients with acute ischemic stroke from Shenzhen Second People′s Hospital in June 2013 to September 2013 were randomly selected as the experimental group , and 50 healthy people as control group , plasma copeptin levels were measured before treatment and 30 days after treatment in both groups ,the MOS item short from health survey （ SF-36 ） and National institute of health stroke scale （ NIHSS ） reduction rate were used to evaluate the prognosis after 30 days.SPSS 20.0 software package was used for data processing .Results Plasma copeptin levels before treatment of the experimental group was significantly higher than that of the control group [（439.03 ±210.91）pg/ml vs.（54.91 ±18.65）pg/ml,t=2.873,P〈0.01].The higher plasma copeptin lever before treatment was,the smaller the NIHSS reduction rate was ,even the NIHSS value increased ,the prognosis and peptide levels before treatment were inversely correlated （ r values were -0.661 ,-0.587 ,-0.734 ,-0.684 ,-0.632 , respectively , all P〈0.001 ） .The SF-36 table was negatively correlated with peptide hormone levels before treatment （ r values were -0.673 , -0.661 , -0.715 , -0.587 , -0.734 ,-0.687 ,-0.635 ,-0.703 ,all P〈0.001 ） .Conclusion The higher plasma copeptin level in patients with acute ischemic stroke before treatment is ,the poorer recent prognosis is .