首发精神分裂症患者血清抗NMDAR抗体水平的研究

Levels of serum anti-NMDAR antibodies in patients with first-episode schizophrenia

目的：研究首发精神分裂症患者血清中抗N－甲基－D－天冬氨酸受体（NMDAR）抗体浓度水平变化。方法用酶联免疫吸附技术（ELISA）测定80名健康对照和82例首发精神分裂症患者血清抗NMDAR抗体浓度水平。结果首发精神分裂症患者组血清抗NMDAR抗体浓度显著高于对照组[（208．84±113．60）pg／ml比（107．29±40．57）pg／ml]，差异有统计学意义（t＝－7．162，P＜0.01）。患者组男、女血清抗NMDAR抗体浓度水平[（215．75±133．20）pg／ml比（200．00±83．14）pg／ml]差异无统计学意义（t＝0．621，P＞0．05）。精神分裂症患者血清抗NMDAR抗体浓度与PANSS总分、阳性症状分及阴性症状分均呈正相关（r值分别为0．364，0．276，0．260；P＜0．05）。结论首发精神分裂症患者血清抗NMDAR抗体水平升高，与精神分裂症临床症状呈正相关。

Objective To explore serum level of anti-NMDAR antibodies in patients with first-episode schizophrenia .Methods The serum concentrations of anti -NMDAR antibodies in 80 healthy controls and 82 patients with first -episode schizophrenia were assessed by enzyme linked immunosor‐bent assay （ELISA） .Results The level of serum anti-NMDAR antibody in first-episode schizophreni‐a was observably higher than healthy controls[（208 .84 ± 113 .60）pg/ml vs（107 .29 ± 40 .57） pg/ml] , and the difference was statistically significant （t = - 7 .162 ,P 〈 0 .01） .The difference of serum anti-NMDAR antibody concentrations between men（215 .75 ± 133 .20）pg/ml and women（200 .00 ± 83 .14）pg/ml in patients with schizophrenia was no statistically significant （t= 0 .621 ,P〉 0 .05） .The serum concentra‐tion of anti -NMDAR antibodies was positively correlated with PANSS total score ,the positive syn‐drome scores and the negative syndrome scores （r= 0 .364 ,0 .276 ,0 .260 ,respectively ;P〈 0 .05） .Con‐clusions The level of serum antibody anti -NMDAR in first -episode schizophrenia is increased ,and there is a positive correlation with the clinical symptoms of schizophrenia .