情感气质与抑郁发作双极性的相关性研究

Relationship between affective temperament and bipolarity in depression episode

目的：分析单相抑郁发作患者的情感气质类型与抑郁发作双极性的关系。方法本研究为横断面研究，入组36例治疗12周的单相抑郁症患者，采集患者的服药情况和评估治疗12周时的临床治愈率。根据Akiskal的软双相谱系理论，运用气质自评量表，将伴有旺盛气质和循环气质的单相抑郁发作归为软双相谱。结果36例患者分为10例（27．8％）软双相谱系患者（9例为临床治愈）和26例严格的单相抑郁患者（18例为临床治愈）。软双相谱系患者的年龄明显低于严格的单相抑郁患者。两组在气质类型，循环气质（P＜0．01）、焦虑气质（P＜0．01）、易激惹气质（P＜0．01）、抑郁气质（P＜0．05）具有明显差异。在10例软双相谱系患者中，心境稳定剂锂盐治疗组的临床治愈率明显高于非锂盐治疗组（P＜0．01）。结论情感气质或许能预测抑郁发作的双极性，心境稳定剂能够改善软双相谱系患者的临床症状，为软双相谱系概念提供了支持性证据。

Objective To explore the relationship between affective temperament and bipolarity in depression episode .Methods This study was a cross-sectional study .Thirty -six unipolar depression patients treated 12 weeks were included ,the medication compliance and the clinical cure rate were col‐lected .The unipolar depression with exuberant and cycle temperament was classified as soft bipolar spec‐trum according with the soft bipolar spectrum theory and the temperament evaluation scale . Results There were 10（27 .8% ） soft bipolar spectrum patients （9 patients were clinically cured） and 26 rigorous unipolar depression（18 patients were clinically cured） .Patients with bipolar spectrum were sig‐nificantly younger than patients with unipolar depression .There were significantly different between bi‐polar spectrum with unipolar depression in affective temperament（i .e .cycle ,anxiety ,irritability and de‐pression temperament） （P 〈 0 .01） .Bipolar spectrum patients with lithium treatment and had signifi‐cantly higher remission rates than patients without lithium treatment （P〈 0 .01） .Conclusions The af‐fective temperament may predict the bipolarity in depression episode ,mood stabilizers can improve clini‐cal symptoms in patients with soft bipolar spectrum ,which provide supporting evidence for the concept of soft bipolar spectrum .