曲美布汀、多潘立酮治疗功能性消化不良的疗效对比分析

Contrastive analysis of Trimebutine and Domperidone effect on functional dyspepsia

目的对比分析曲美布汀、多潘立酮治疗功能性消化不良(FD)的疗效及安全性。方法将106例功能性消化不良患者分为两组:对照组53例和观察组53例。对照组给予多潘立酮,观察组给予曲美布汀,疗程均为4周。比较两组疗效、主要症状、复发情况及不良反应。结果观察组患者治疗显效率和总有效率均明显高于对照组(P<0.05);观察组患者餐后饱胀、上腹胀、嗳气、恶心、呕吐等症状发生率均明显低于对照组(P<0.05);观察组患者6个月后复发率明显低于对照组(P<0.05);两组不良反应发生率无明显差异(P>0.05)。结论曲美布汀治疗功能性消化不良的疗效优于多潘立酮,安全性好,适合临床推广应用。

Objective Contrastively analyze the effect and security of trimebutine and domperidone on functional dyspepsia （ FD ） .Methods Divided 106 cases of FD patients into observation group and control group, with 53 cases in each group.Gave domperidone to the control group and trimebutine to the observation group with a four-week course of treatment respectively.Compared the effect, cardinal symptom, recurrence and untoward effect of the groups.Results The significant efficiency and total effectiveness of the treatment in the observation group was apparently higher than that in the control group （P〈0.05）;Occurrence rate of symptoms including postprandial fullness, epigastric distention, belching, nausea, emesis in the observation group was apparently lower than that in the control group （ P〈0.05 ）; Recurrence rate in the observation group after 6 months was apparently lower than that in the control group （ P 〈0.05 ）; There was no significant difference between the groups in untoward effect occurrence rate （P〉0.05）.Conclusions Trimebutine shows better effect on FD than Domperidone with higher security, and is suitable for wide clinic application.