新辅助放化疗对直肠癌治疗效果的影响

Effect of neoadjuvant chemotherapy in the treatment of rectal cancer

目的分析新辅助放化疗对直肠癌治疗效果的影响。方法该研究选取2008年7月-2010年6月120例直肠癌患者为对象,回顾性分析其临床资料,根据其放化疗时间分组。术后放化疗患者56例纳入对照组,术前新辅助放化疗患者64例纳入试验组。术后随访5年,对比分析两组患者术后并发症发生率,术后1、3、5年局部复发率,远处转移率,死亡率的差异。结果对照组和试验组患者术后并发症发生率无显著的统计学差异(P>0.05)。两组术后1年局部复发率、远处转移率、死亡率差异无显著统计学意义(P>0.05)。试验组患者术后3、5年局部复发率、远处转移率、死亡率均明显低于对照组,差异有统计学意义(P<0.05)。结论直肠癌患者术前进行放化疗有助于保证手术效果,降低局部复发率、远处转移、死亡等不良后果的发生风险,具有更好的远期疗效。

[ Objective ] Analysis of neoadjuvant chemotherapy on colorectal cancer therapeutic effect. [ Methods ] This study selected from July 2008 to June 2010 120 cases of coloreetal cancer patients as objects, retrospective analysis of clinical data, grouped according to its time of radiotherapy and chemotherapy. Postoperative radiotherapy and chemotherapy patients in the control group included 56 cases, preoperative neoadjuvant chemotherapy in patients with 64 cases included in the experimental group. Patients were followed up for 5 years, the two groups were analyzed postoperative complication rate, after 1 year, 3 years, the difference of local recurrence and distant metastasis rate, mortality rate of five years. [ Results ] Patients in the control group and the experimental group the incidence of complications was no significant statistical difference （/9〉0.05）. 1-year postoperative local recurrence rate, distant metastasis and mortality difference was not statistically significant （P〉0.05）. Experimental group patients 3 years, 5-year local recurrence rate, distant metastasis, mortality was significantly lower than the control group, the difference was statistically significant （P〈0.05）.Patients in the control group and the experimental group the incidence of complications was no significant statistical difference （P〉0.05）. 1-year postoperative local recurrence rate, distant metastasis and mortality difference was not statistically significant （P〉 0.05）. Experimental group patients 3 years, 5-year local recurrence rate, distant metastasis, mortality was significantly lower than the control group, the difference was statistically significant （P〈0.05）. [ Conclusion ] Preoperative chemotherapy in patients with colorectal cancer surgery helps to ensure effectiveness, reduce the local recurrence rate, distant metastasis, the risk of death and other adverse consequences, it has better long-term outcome.