液基薄层细胞学检测在宫颈上皮内瘤变和宫颈癌诊断中的应用价值分析

The application of TCT in the diagnosis of cervical epithelial lesions and cervical cancer

目的：探讨液基薄层细胞学技术（TCT）在诊断宫颈上皮内瘤变及宫颈癌中的应用价值。方法：选取2012年6月至2013年12月期间在我院接受宫颈病变筛查的681例患者作为研究对象，行 TCT检查及阴道镜下宫颈活检，探讨年龄与发病率的关系，同时对比研究 TCT 细胞学与组织学诊断结果。结果：TCT 阳性率多见于36～45岁年龄段；TCT 细胞学诊断 ASC －H 60例，ASC －US 222例，LSIL 89例，HSIC 14例，SCC 5例，AGC 2例；组织学诊断 CINI 178例，CINⅡ114例，CINⅢ33例，SCC 13例，以组织学诊断为金标准，ASC －H 符合率为91.67％（55／60），ASC －US 为34.23％（76／222），LSIL 为87.64％（78／89），HSIC 为92.86％（13／14），SCC 为100％（2／2）。结论：液基薄层细胞学技术（TCT）具有较高的阳性检出率，是筛查宫颈上皮病变的重要手段，有助于宫颈上皮内瘤变和宫颈癌的早期诊断及治疗。

Objectives：To investigate the application value of TCT in the diagnosis of cervical epithelial le-sions and cervical cancer.Methods：681 patients that received cervical lesions screening in our department from June 201 2 to December 201 3 were selected and were tested by TCT and colposcopy cervical biopsy.The relationship between age and incidence rate was explored,and results of TCT cytological and histological diagnosis were com-pared.Results：The positive rate of TCT was higher in patients of 36 ~45 years old.There were ASC -H （60 ca-ses）,ASC -US （222 cases）,LSIL（89 cases）,HSIC （1 4 cases）,SCC （5 cases）and AGC （2 cases）diagnosed by TCT cytology,and 1 78 cases of CINI,1 1 4 cases of CIN II, 33 cases of CIN III and 1 3 cases of SCC diagnosed by TCT.Choosing histological diagnosis as the gold standard,the coincidence rate of ASC -H,ASC -US,LSIL, HSIC and SCC were 91 .67% （55 /60）,34.23% （76 /222）,87.64% （78 /89）,92.86% （1 3 /1 4）and 1 00%（2 /2）respectively.Conclusion：With a high positive rate,TCT is an important screening means for cervical intra-epithelial lesions,which is conducive to early diagnosis and treatment of cervical intraepithelial neoplasia and cervi-cal carcinoma.