摘要
目的:探讨曲唑酮对帕罗西汀所致性功能障碍的作用。方法:选取服用帕罗西汀后出现性功能障碍者共53例,入組后合并曲唑酮治疗,1周内渐加至100mg^200mg/d,观察4周。分别于入组时、2周末、4周末进行汉密尔顿抑郁量表HAMD-17、性健康量表(SHS)、勃起障碍评定量表(EDRS)、治疗时副反应量表(TESS),分别评定抑郁程度、性生活满意度、勃起功能及不良反应。结果:干预2、4周末,HAMD评分与入组时比较虽有所降低,差异无统计学意义(P>0.05);EDRS评分2周末与入组时比较差异有统计学意义(P<0.05),说明曲唑酮对帕罗西汀所致的勃起障碍有明显的改善作用;至4周末这一趋势更为明显,差异有统计学意义(P<0.01);干预2、4周末,SHS评分与入组时比较显示了与EDRS类似结果;不同的是4周末SHS评分与2周末比较差异明显(P<0.05)。结论:曲唑酮对帕罗西汀所致的性功能障碍有明显的改善作用,值得在今后临床中推广应用。
Objectives: To explore the effects of trazodone on sexual dysfunction caused by paroxetine. Methods: 53 patients with sexual dysfunction caused by paroxetine were selected and all treated with trazodone as well as paroxetine. The dose of trazodone was gradually increased to 100mg- 200mg/d in a week, and kept observation for 4 weeks. Hamilton Depression Scale (HAMD - 17 ), Sexual health Scale (SHS), Erectile Dysfunction Rating Scale (EDRS) and Treatment Emergent Symptom Scale (TESS) were used to assess depressive degree, sex- ual satisfaction, erectile dysfunction and adverse reactions respectively at the time of enrollment, end of 2 weeks and 4 weeks. Results: Compared with the baseline, the score of HAMD decreased after 2 and 4 weeks' intervention, but the difference was not statistically significant (P 〉 0.05). The EDRS score on the end of 2 weeks was significandy different compared with the baseline ( P 〈 0.05 ), which showed that there was obvious improvement of trazodone in the treatment of erectile dysfunction induced by paroxetine. This trend was more obvious at the end of 4 weeks, with statistically significant difference (P 〈 0.01 ) ; after 2 weeks' and 4 weeks' intervention, the score of SHS compared with the baseline showed similar results with the EDRS. The difference in the score of SHS at the end of 4 weeks was significant compared with that at the end of 2 weeks ( P 〈 0.05 ). Conclusions: Trazodone can significantly improve sexual dysfunction caused by paroxetine, which is worthy of clinical popularization and application in the future.
出处
《中国性科学》
2015年第9期13-15,共3页
Chinese Journal of Human Sexuality