血清骨桥蛋白及中性粒细胞明胶酶相关脂质运载蛋白水平在多囊卵巢综合征中的临床意义

Clinical significance of levels of serum osteopontin and neutrophil gelatinase- associated lipocalin in patients with polycystic ovary syndrome

目的:探讨多囊卵巢综合征(PCOS)患者血清骨桥蛋白(OPN)与中性粒细胞明胶酶相关脂质运载蛋白(NGAL)的水平及其临床意义。方法:62例PCOS患者及同期健康体检的30例正常对照者分别采用酶联免疫法(ELISA)检测血清OPN和NGAL的水平,同时根据体重指数(BMI)将PCOS患者分为肥胖组32例(BMI≥25kg/m2)和非肥胖组30例(BMI<25kg/m2)。结果:与正常对照组相比较,所有PCOS患者血清中OPN和NGAL含量均显著偏高;肥胖PCOS患者血清中的OPN和NGAL水平也均明显高于非肥胖PCOS患者,差异具有统计学意义(P<0.05)。此外,Pearson相关分析结果显示血清OPN及NGAL均与BMI、胰岛素抵抗指数(HOMA-IR)呈正相关性,与胰岛素敏感指数(ISI)呈负相关性,差异具有统计学意义(P<0.05)。结论:多囊卵巢综合征患者血清中OPN和NGAL水平均处于升高状态,提示PCOS患者机体处于一种慢性炎性状态,未来可将减缓机体炎性状态作为治疗PCOS患者的策略之一。

Objectives：To investigate clinical significance of levels of serum osteopontin and neutrophil ge-latinase -associated lipocalin in patients with polycystic ovary syndrome.Methods：The levels of serum levels of OPN and NGAL of 62 PCOS patients and 30 healthy people as normal control were detected by using enzyme -linked immunoassay （ELISA）.According to body mass index （BMI）,patients with PCOS were divided into two groups：32 cases in obese group （BMI≥25kg/m）2 and 30 cases in non -obese group （BMI 〈25kg/m2 ）.Results：Compared with normal control group,OPN and NGAL content in all PCOS patients were significantly higher.And OPN and NGAL levels of PCOS patients with obese were significantly higher than these of non -obese PCOS patients （P 〈0.05）.In addition,Pearson correlation analysis results showed that there was a positive correlation between the serum levels of OPN and NGAL and BMI,insulin resistance index （HOMA -IR）（P 〈0.05）.Conclusions：Polycystic ovary syndrome patients were under a state of elevated serum levels of OPN and NGAL,which may indi-cate that the PCOS patients maybe in a state of chronic inflammatory.In future,slowing down the body’s inflamma-tory state may become a part of the strategy for the treatment of patients with PCOS.