CO_2激光联合甘露聚糖肽注射液治疗尖锐湿疣的临床研究

Clinical study of CO_2 laser combined with Mannatide injection in the treatment of condyloma acuminatum

目的:观察CO2激光联合甘露聚糖肽注射液治疗尖锐湿疣的临床疗效,以期为尖锐湿疣的治疗提供借鉴。方法:选取在2009年4月至2012年6月以来我院和济南市中心医院就诊的尖锐湿疣患者120例为研究对象,并随机分为两组,治疗组和对照组,对照组予以单纯CO2激光治疗,治疗组在CO2激光治疗的基础上合用甘露聚糖肽注射液静滴治疗。观察其治愈情况及预防复发的临床效果。结果:两组尖锐湿疣患者在性别、年龄和体重差别均无统计学意义(P>0.05)。两组治愈率分别为83.87%、51.72%,进行卡方检验,χ2=7.493,P=0.024<0.05,差异有显著性意义,治疗组优于对照组;治疗组第一个月复发的例数4例,占6.15%,第二个月复发的例数2例,占3.23%,第三个月复发的例数2例,占3.23%;对照组第一个月复发的例数6例,占10.34%,第二个月复发的例数8例,占13.79%,第三个月复发的例数14例,占24.14%,对复发率行秩和检验,z=1.482,P=0.138>0.05,无显著差异。结论:CO2激光联合甘露聚糖肽注射液治疗尖锐湿疣的临床疗效,为尖锐湿疣的治疗提供借鉴,值得推广。

Objectives：To investigate the clinical efficacy of CO2 laser combined mannatide injection in the treatment of genital warts in order to provide reference for the treatment of genital warts.Methods：120 patients with genital warts in our hospital from April 2009 to June 2012 were selected and randomly divided into the treatment group and the control group.The control group was given CO2 laser treatment,while treatment group was given addi-tional mannatide intravenous injection on the basis of CO2 laser treatment.The cure and prevention of relapse results were compared.Results：Differences in gender,age and weight between the two groups were not statistically signifi-cant （P 〉0.05）.The cure rates of the two groups were 83.87% and 51.72%,（χ2 =7.493,P =0.024 〈0.05） with significant difference.There were 4 cases （6.15%）,2 cases （3.23%）and 2 cases （3.23%）of relapse in the treatment group in the first,second and third month,while 6 cases （10.34%）,8 cases （13.79%）,and 14 cases （24.14%）in the control group respectively （z =1.482,P =0.138 〉0.05）without significant difference. Conclusions：CO2 laser combined with mannose glycans injection is of good clinical efficacy in the treatment of gen-ital warts,providing reference for the treatment of genital warts,which is worthy of promotion.