早期筛查及治疗对妊娠期细菌性阴道病的意义

Significance of early screening and treatment on bacterial vaginosis in pregnancy

目的:探讨早期筛查及治疗对妊娠期细菌性阴道病(Bacterial vaginosis,BV)的意义。方法:对326例晚期妊娠孕妇行BV筛查,了解妊娠期BV的发病率。将BV阳性孕妇随机分成三组,甲组采用保妇康栓治疗,乙组采用乳酸菌阴道胶囊治疗,丙组未采取治疗措施。326例孕妇随访至妊娠终止。观察所有孕妇绒毛膜羊膜炎,胎膜早破、早产的发病情况。结果:妊娠期BV的发病率为19.63%(64/3265),保妇康栓治疗BV有效率为91.30%,乳酸菌阴道胶囊治疗BV有效率为80.0%,二者具有显著性差异(P<0.05)。A组(BV阳性组)、B组(经治疗BV转阴组)、C组(BV阴性组)之间的绒毛膜羊膜炎、早产发生率差异均有统计学意义(P<0.05),A组与B组、C组的胎膜早破发生率差异均有统计学意义(P<0.05),而B组与C组两组组间的胎膜早破发生率差异无统计学意义(P>0.05)。结论:妊娠期BV在不同的孕周均有较高的发病率,应给予早期筛查,保妇康栓治疗BV疗效肯定。

Objectives：To investigate the significance of early screening and treatment on bacterial vagino-sis in pregnancy.Methods：326 cases at different gestational age after 28 weeks of pregnancy were selected for BV screening in order to learn the incidence of bacterial vaginosis in pregnancy.BV positive cases were randomly divid-ed into three groups：23 cases were given baofukang suppository;20 cases were given lactobacillus vaginal capsules and 21 cases did not received treatment.These women were followed up until the termination of pregnancy.The chorioamnionitis,premature rupture of membranes and premature birth incidence were observed.Results：The BV incidence in pregnancy was 19.63% （64 /216）;the efficacy of baofukang suppository in treatment of BV was 91.30%,while the efficacy of lactobacillus vaginal capsules was 80.0%,with significant difference （P 〈0.05）.nbsp;Differences in incidence of chorioamnionitis,and premature birth among Group A （BV positive）and group B （BV turned negative after treatment）and group C （BV negative）were statistically significant （P 〈0.05）as well as difference in incidence of chorioamnionitis between group A and group B,group A and group C,but there was no statistically significant difference between group B and group C.Conclusions：BV in pregnancy has a high inci-dence at different gestational ages,which should be screened early.Baofukang suppository is effective in treatment of BV.