青海高原成人发热呼吸道症候群病毒病原学分析

Analysis on viral of adult with febrile respiratory syndrome in plateau of Qinghai province

目的了解青海高原成人发热呼吸道症候群病例的主要病毒病原及其流行特征。方法收集2010-2014年青海省一家综合性医院就诊的18岁以上急性呼吸道感染病例的基本信息及临床信息,采集鼻咽拭子标本进行流感病毒、呼吸道合胞病毒、腺病毒、副流感病毒、偏肺病毒、冠状病毒、博卡病毒和鼻病毒8种病毒的Real-time PCR检测。结果 227例发热呼吸道症候群病例病毒检出率为12.33%,主要为人流感病毒,占阳性标本构成比的42.86%;其次为人副流感病毒和鼻病毒,分别占21.43%、17.86%。春季和冬季为病毒感染的高峰季节(χ2=11.841,P<0.05)。结论青海高原地区成人发热呼吸道症候群病例主要以流感病毒、人副流感病毒和鼻病毒感染为主。

Objective To study the pathogens and distributions for cases of children with febrile respiratory syndrome in plateau of Qinghai province. Methods To collect the basic information such as age, gender, nations, et al and the clinical information of the patients above 18 years with febrile respiratory syndrome from a hospital in Qinghai province. Nasopharyngeal swabs from these patients were collected and Real -time RT- PCR method were used to detected human adenovirus （ADV）, influenza virus （FLu）, parainfluenza virus （PIV）, novirus was 12. fluenza bocavirus （BocaV）, respiratory syscytial virus （RSV） （HRV） and human coronavirus （HcoV） . Results 227 33% , and the major pathogen was influenza virus by the , human metapneumovirus （HMPV）, rhicases were collected, detection rate of virus rate of 42. 86%, followed by human parainvirus （21.43%） and rhinovirus （ 17.86% ） . The peak season of infection was spring and winter. （χ^2 = 11. 841, P 〈 0. 05） . Conclusions The major virus of adult with febrile respiratory syndrome in Qinghai plateau were influenza virus , parainfluenza virus and rhinovirus.