Dyrk1B在宫颈癌组织中的表达及其临床意义

Expression and clinical significance of Dyrk1B in cervical carcinoma

目的探讨Dyrk1B在宫颈癌组织中的表达及其临床意义。方法利用免疫组化检测Dyrk1B在60例宫颈癌组织、60例宫颈癌癌旁组织和60例正常宫颈组织中的表达，分析Dyrk1B在宫颈癌组织中的表达状况以及与宫颈癌临床参数的关系。结果Dyrk1B在宫颈癌组织中的表达（60／60，100％）明显高于癌旁组织（26／40，65％）和正常宫颈组织（16／40，40％），三组间比较差异有统计学意义（χ2=88．21，P〈0．01）。Dyrk1B的强阳性率与宫颈癌的组织学分化程度有明显相关性（P〈0．05），与宫颈癌患者的年龄、临床分期和有无淋巴转移等无明显相关性（P〉0．05）。结论Dyrk1B在宫颈癌中高表达，提示其可能参与了肿瘤的发生和发展，并有望成为宫颈癌早期诊断的标志物和治疗的靶基因。

Objective To investigate the expression of DyrklB in cervical cancer and its clinical significance. Methods Immunohistochemical methods were used to detect the expression levels of DryklB in 60 cases cervical carcinoma tis- sues, 60 cases of cervical cancer adjacent tissues and 60 cases normal cervical tissues. DryklB expression in cervical carcinoma and relationship with clinical parameters of cervical carcinoma. Results The expression of DyrklB in cervi- cal cancer tissues was significantly higher than that in cervical cancer adjacent tissues and normal cervical tissues, and there was statistical significance between the three groups（χ2=88.21 ,P〈0.01）. There was a significant correlation be- tween the strong positive rate of Dyrklb and degree of histological differentiation（P〈0.05）,but there was no correlation between the strong positive rate of Dyrklb and patient＇s age, clinical stage and lymph node metastasis of cervical car- cinoma（P〉0.05）. Conclusion The expression level of Dyrklb in cervical carcinoma tissues is high,which indicates that it may participate in the occurrence and development of cervical carcinoma , and it may become a tumor marker for clinical early diagnosis and a new target gene for. treatment of cervical carcinoma.