氟西汀治疗糖尿病痛性神经病变的疗效分析

The effect of fluoxetine in treatment of patients with painful diabetic peripheral neuropathy

目的观察氟西汀治疗糖尿病痛性神经病变的临床疗效。方法将2014年1月-2015年1月我院收治的60例糖尿病合并糖尿病痛性神经病变患者随机分为治疗组（A组）和对照组（B组），每组各30例，A组患者给予氟西汀治疗，B组患者给予安慰剂治疗，治疗观察8周，比较治疗前后血糖水平、测量正中神经、腓总神经运动神经传导速度及感觉神经传导速度。结果治疗组的临床缓解率明显高于对照组．治疗组患者的正中神经感觉传导速度、腓总神经感觉传导速度显著加快，且优于对照组（P〈0．05），而对照组无明显变化。两组患者治疗前后FBG、2hPG比治疗前下降但差异无统计学意义（P〉0．05）。结论采用氟西汀治疗糖尿病伴瘠J生神经病变效果明显，还可控制血糖，值得临床推广。

Objective To observe the clinical efficacy of fluoxetine in the treatment of patients with painful diabetic peripheral neuropathy （PDPN）. Methods A total of 60 T2DM patients with PDPN in our hospital from January 2014 to January 2015 were randomly divided into two groups, treatment group （group A, n=30） and control group （group B, n=30）. After treated for 8 weeks, blood glucose level, the nerve conduction velocity of median nerve, common nerve and sensory nerve of the two groups were compared before and after the treatment. Results Compared with control group, clinical remission rate of the treatment group was higher. In the treatment group, the MNCC and SNCV were significantly ac- celerated and better than the control group （P〈0.05）, while there was no obvious changed in control group. The fasting blood glucose and postprandial two hour blood glucose were decreased compared with pre-treatment in two groups （P〉0.05）. Conclusion Fluoxetine has a good effect on diabetic patients with painful neuropathy, it can control blood glucose, and is worthy of promotion.