盐酸米诺环素与甲硝唑药膜治疗牙周炎的疗效比较

A curative effect comparative of minocycline hydrochloride and metronidazole membrane in treatment of periodontitis

目的对比甲硝唑与米诺环素治疗牙周炎的效果。方法将124例牙周炎患者分为A组与B组,每组62例,A组应用盐酸米诺环素治疗,B组应用甲硝唑药膜治疗,比较两组的疗效、各项观察指标的变化及不良反应。结果A组的总有效率为90.32%,B组为75.81%,A组的总有效率高于B组;治疗前两组GI、PLI、PD、SBI、AL及TM值比较差异无统计学意义,治疗后两组各项观察指标比较差异有统计学意义(P<0.05)。A组总不良反应发生率明显低于B组(P<0.05)。结论米诺环素治疗牙周炎的效果优于甲硝唑,安全性好。

Objective To compare the effect of metronidazole and minocycline in treatment of patients with periodontitis. Methods A total of 124 cases of periodontitis were divided into group A and group B, 62 cases in each group, group A used minocycline hydrochloride treatment, group B used metronidazole membrane treatment, the efficacy and the index changes and adverse reactions was compared between the two groups. Results The total effective rate of group A was 90.32%. The total effective rate of group B was 75.81%, the total efficiency of group A was better than the group B; GI, PLI, SBI and PD, AL and TM values of two groups before treatment had no difference（P〉0.05）. After treatment, the difference above index was statistical significant （P〈0.05）. The total rate of adverse reaction of group A was statistically lower than that in the group B（P〈0.05）. Conclusion Minocycline in treatment of periodontitis is superior to metronida- zole, and it has good safety.