脑利钠肽和CA125在老年舒张性心力衰竭诊治中的评价

Evaluation of brain natriuretic peptide and CA125 in diagnosis and treatment of senile diastolic heart failure

目的测定老年舒张性心力衰竭(DHF)患者治疗前、后血浆脑利钠肽(BNP)和糖类抗原125(CA125)的水平,探讨老年DHF时BNP和CA125的变化及其意义。方法 60例老年DHF患者为老年DHF组,60例心功能正常者作为对照组。检测老年DHF组患者治疗前后和对照组的血浆BNP和CA125浓度。结果 1老年DHF组血浆BNP和CA125浓度明显高于对照组,差异有统计学意义(P<0.05)。2老年DHF组治疗后血浆BNP和CA125浓度均显著下降,差异有统计学意义(P<0.05)。结论血浆BNP和CA125在老年DHF患者中明显升高,对疗效观察和病情转归有一定临床指导意义。

ObjectiveTo detect plasma brain natriuretic peptide （BNP） and carbohydrate antigen 125 （CA125） in senile diastolic heart failure （DHF） patients before and after treatment, and to investigate changes and significance of BNP and CA125 in senile DHF.MethodsThere were 60 senile DHF patients as senile DHF group, and another 60 people with normal cardiac function as control group. Plasma BNP and CA125 were detected in senile DHF group and control group before and after treatment.Results① Senile DHF group had obviously higher plasma BNP and CA125 levels than the control group, and their difference had statistical significance （P〈0.05）. ② Senile DHF group had remarkably reduced plasma BNP and CA125 levels after treatment, and the difference had statistical significance （P〈0.05）.ConclusionObviously increased plasma BNP and CA125 levels in senile DHF patients provide certain clinical guidance significance for curative effect observation and disease outcomes.